Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 216-235 of 347
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Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation
(2010-11-19)Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene ... -
Molecular mechanisms of human presynapse assembly - role of liprin-alpha proteins in synapse organization and neurological disease
(2024-04-18)Synapses are the essential transmission units of neuronal circuits and represent the cornerstone of our unique cognitive abilities. During synapse formation, contact between two neurons induce the assembly of pre- and ... -
Molecular regulation of epithelial tube size
(2009-02-27)In nature, epithelial tubes are vital structures in organ design and are required for transport of gases and liquids in organs, such as the vascular system, the vertebrate lung and the kidneys. The tubular epithelium is ... -
Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer
(2012-10-08)Cervical cancer is the second most common cancer among women worldwide with half a million of new cases every year. Cervical cancer is caused by oncogenic human papillomaviruses (HPVs), with HPV16 and 18 being the most ... -
A mouse model for direct evaluation of cholera vaccines
(2009-04-23)Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup ... -
The MUC2 mucin -A network in the intestinal protective mucus
(2009-05-26)The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily ... -
Mucin-like proteins in Drosophila development
(2014-01-17)Mucins are large and highly glycosylated proteins and major component of the mucus that coats the lining of epithelial organs. Mucins are characterized by the presence of extended regions rich in the amino acids Proline, ... -
Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ... -
Mucus and mucins during gastrointestinal infections
(2014-03-24)The gastrointestinal tract is protected by a continuously secreted mucus layer formed by mucin glycoproteins. The mucus layer and mucins change dynamically during infection. The main focus of this thesis was to investigate ... -
Mucus associated proteins and their functional role in the distal intestine
(2014-11-28)The mammalian intestine, especially the large intestine, harbors complex societies of beneficial bacteria coexisting with the host. This is a mutualistic relationship, where the host provides nutrients and a favorable ... -
Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis
(2014-11-06)Today, more than half of the world’s population is infected with Helicobacter pylori, and two to three per cent of these will develop gastric cancer associated with this infection. Gastric cancer is today the third largest ... -
Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy
(2024-02-07)Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ... -
Multiple primary malignancies in breast cancer patients. From population study to genetics
(2021-04-16)Breast cancer (BC) is one of the most common causes of cancer-related death among women worldwide. Due to early detection of BC and more tailor-made treatments, patients live longer despite their illness. Studies have shown ... -
Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity
(2017-09-01)CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective ... -
Neoehrlichiosis - latent infection of endothelium and immune defense
(2023-11-14)This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense ... -
Neural stam cells, TLX, and Neuroblastoma
(2014-09-19)Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of ... -
The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
(2009-09-30)Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment ... -
New Roles of Filamins in Cell Signaling, Transcription and Organ Development
(2009-03-12)Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell ... -
Next generation molecular diagnostics using ultrasensitive sequencing
(2022-03-15)Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to ... -
Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
(2019-10-30)Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem ...