Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 127-146 of 345
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Genetic Studies of Psoriasis and Psoriatic Arthritis
(2008-02-08)Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop ... -
Genetic studies of the regulation of bone parameters and serum testosterone
(2018-05-29)Osteoporosis is a common disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased risk of fracture and represents a huge economic burden on health care systems. The ... -
Genetics and functions of innate-like lymphocyte subsets
(2007-09-21)The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the ... -
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ... -
Genomic and transcriptomic profiles in chronic hepatitis B infection
(2023-05-04)Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are ... -
Genomic instability and genetic heterogeneity in neuroblastoma tumours
(2017-11-03)Javanmardi, N., 2017, Genomic instability and genetic heterogeneity in neuroblastoma Department of Pathology and Clinical Genetics, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Sweden Neuroblastoma ... -
Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection
(2022-01-19)Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ... -
Genomic signatures in viruses
(2023-05-25)In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, ... -
Geographic and genetic diversity of hepatitis B
(2011-01-04)Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead ... -
The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
(2008-02-01)During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate ... -
Giant Cell Arteritis - Pathogenetic and Epidemiological Aspects
(2012-01-20)Giant cell arteritis (GCA) is a chronic inflammatory disorder of medium-size and large arteries which affects people aged 50 years or older with a female preponderance. The two different expressions of GCA are temporal ... -
Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches
(2021-03-26)Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with ... -
Glycoproteomics incursions into the realm of proteoglycans
(2017-02-09)The term proteoglycan encompasses a heterogeneous group of heavilymodified metazoan glycoproteins that are involved in fundamental biological processes. They are essential for embryonic development and play important roles ... -
Granulocyte activation by danger signals and blocking of receptor responses
(2007-10-09)Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged ... -
Growth regulation in thyroid development
(2018-05-07)The fundamental aspects of developmental mechanisms that regulate embryonic and postnatal thyroid growth gaining the final size of the gland are still largely undetermined. In embryonic development, various organs and ... -
Healing Cartilage - aspects on regenerative methods
(2013-11-27)Articular cartilage has poor intrinsic capacity to heal and defects can cause severe pain for the patient. If the healing process is not assisted the damage might deteriorate and lead to the onset of osteoarthritis. ... -
Helicobacter spp. interactions with mucins: adhesion and mucin regulation of pathogen proliferation and gene expression
(2014-02-10)Helicobacter pylori colonizes the gastric mucosa of approximately half of the world’s population and is a risk factor for gastritis, peptic ulcers and gastric cancer. H. pylori is surrounded by, and adheres to, the heavily ... -
Helicobacter spp. – host interaction in the mucus niche
(2018-11-30)Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter ... -
Hepatitis B virus replication and integration
(2014-04-11)Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no ... -
Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR
(2019-12-19)Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify ...