Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 107-126 of 345
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Forkhead genes in adipocytes and podocytes
(2016-10-27)Forkhead genes are a family of transcription factors with important functions in development and metabolism. This thesis addresses tissue-specific functions of the two forkhead genes, FOXC2 and FOXF2, using transgenic mouse ... -
Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
(2010-05-28)Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. Studies included ... -
Foxi1, an important gene for hearing, kidney function and male fertility
(2007-08-27)Aim: In this study we focused on the biological importance of the forkhead transcription factor Foxi1. The overall aim was to elucidate the functional role of Foxi1 in the inner ear, kidney and epididymis. When mice ... -
From 1p3 to PI3K - Studies of neuroblastoma
(2011-01-19)Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is ... -
Function of natural killer cells in Helicobacter pylori infection and gastric cancer
(2011-02-22)Helicobacter pylori infection is one of the most wide-spread infections in the world and causes a chronic inflammation in the gastrointestinal mucosa characterised by increased production of IFN-γ and is associated with ... -
Functional and Phenotypic Studies of Eosinophilic Granulocytes in Patients with Eosinophilic Esophagitis
(2015-04-27)Eosinophilic Esophagitis (EoE) is a chronic inflammatory disorder of unknown etiology, in which the esophagus is infiltrated by eosinophils and T cells. Topical corticosteroids are one of the treatment options for patients ... -
Functional characterization of the secretory pathway and the role of COPI vesicles
(2007-12-18)In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How ... -
Functional genetic studies of Psoriasin: a potential biomarker for breast cancer with a poor prognosis
(2010-02-12)Breast cancer is the most common malignancy in women. There is a high degree of heterogeneity in breast tumours and they can be divided into subtypes that have different expression pattern and clinical outcome. Ductal ... -
The functional role of the MUC17-based glycocalyx
(2023-04-27)Our gastrointestinal tract harbors trillions of bacteria that are chemically and spatially separated from the intestinal epithelium. Maintaining an intact mucosal barrier is essential as increased bacterial contact is ... -
Functional studies of two forkhead genes
(2010-01-14)Forkhead genes are functionally diverse and several have been linked to human disease. A previous screen for forkhead genes identified the family member FOXS1. To characterize the function of this gene, we produced a mouse ... -
Functions of glycoprotein G of herpes simplex virus type 2
(2010-02-19)Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection with more than 500 million individuals infected world-wide. A major global health problem is that HSV-2 infection facilitates the ... -
Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines
(2019-11-06)Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious ... -
General awareness of HIV, tuberculosis co-infections and the quality of life among patients with HIV in Xinjiang, in western China
(2015-05-22)Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are major public health problems, particularly in low and middle-income countries. China has the second-highest number of TB cases per year ... -
Genetic and molecular regulation of epithelial tube morphogenesis
(2006-09-29)Networks of epithelial tubes, such as the vertebrate lung, kidney and vascular system, enable transport of gases and nutrients to all tissues in the body. These tubes are built up by a single layer of polarized epithelial ... -
Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer
(2022-08-12)Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric ... -
Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription
(2015-09-16)Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors ... -
Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
(2009-03-06)Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response ... -
Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
(2007-11-12)Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack ... -
Genetic studies of children with mental retardation
(2013-02-20)Mental retardation (MR) is characterised by significant limitations in intellectual function and adaptive behaviour. It is estimated that MR affects up to 3% of the population in Europe. Patients with MR are an aetiologically ... -
Genetic studies of craniosynostosis with focus on syndromic forms
(2022-10-21)Craniosynostosis (CS) represents the premature closure of skull sutures and affects ~1 in 2500 children. Untreated CS can lead to significant complications in craniofacial and psychomotor development. The only treatment ...