Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 307-326 of 345
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T cells in colon cancer; migration and effector functions
(2021-12-16)Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated ... -
Targeting NOX2 in cancer
(2018-02-27)Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a ... -
Targeting residual malignant cells in myeloid leukemia
(2023-05-12)Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated ... -
Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites
(2012-02-10)Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- ... -
TGF-beta signaling in cancer
(2010-11-19)Transforming Growth Factor beta (TGF-beta) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-beta functions as ... -
The breast cancer microenvironment and cancer cell secretion - specific effects on cancer progression and subtypes of cancer cells
(2021-01-22)Breast cancer is the cancer form responsible for the most cancer-related deaths among women worldwide, and novel targeted therapies are highly needed. The tumor microenvironment consists of several components, including ... -
The clinical importance of non-HLA specific antibodies in kidney transplantation
(2015-06-16)The clinical significance of human leukocyte antigen (HLA) antibodies (Abs) for hyperacute, acute and chronic antibody-mediated rejection (AMR) of kidney allografts has been clearly demonstrated. AMR occurs in the absence ... -
The immunomodulatory function of staphylococcal superantigen on oral tolerance
(2010-10-08)Exposure to soluble proteins via the gut gives rise to systemic tolerance, a phenomenon called oral tolerance. Failure of oral tolerance results in allergy, a disease that has increased during the last decades in Western ... -
The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome
(2021-08-18)Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting ... -
The protective role of Nrf2/Keap1 in neurological disease and oxidative stress-induced cell damage
(2013-05-22)Oxidative stress is a common feature in the pathogenesis of many diseases, including neurodegenerative diseases like Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Nrf2 and Keap1 regulate an inducible ... -
The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine
(2012-10-26)The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that ... -
The role of dendritic cells in adjuvant-induced immune responses
(2013-03-07)Dendritic cells (DCs) are sentinels of mucosal surfaces, residing directly under the epithelial layer. DCs are among the first cells that come in contact with pathogens and have the unique ability to activate T cells that ... -
The Role of FCGBP in Mucus - Structure, Processing and Function
(2021-10-26)In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in ... -
The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
(2017-08-07)Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that ... -
The role of IL-17A and IFNγ in vaccine-induced protection against Helicobacter pylori
(2013-11-22)It is estimated that half the world’s population is infected with Helicobacter pylori in the stomach. Chronic H. pylori infection can lead to peptic ulcer disease or gastric cancer, but only in a sub-population of infected ... -
The role of intestinal dendritic cells and the microbiota during oral Salmonella infection
(2015-11-26)The intestinal pathogen Salmonella causes millions of infections per year worldwide. The immune response to these bacteria involves interactions between several cell types via specific molecules and is under the influence ... -
The role of wastewater in surveillance and emergence of antibiotic resistant bacteria
(2021-05-25)As antibiotic resistance spreads among bacterial pathogens, it reduces treatment options and increases treatment failures of infectious diseases. Strategies employed to reduce this spread or adapt to its consequences ... -
Tick-borne encephalitis - clinical and virological aspects
(2021-01-05)Tick-borne encephalitis (TBE), an important central nervous system infection in Europe and Asia, is caused by the TBE virus (TBEV), which is mainly transmitted to humans through tick bites. This thesis studied data from ... -
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Trafficking of Human Dendritic Cells and B cells in Helicobacter pylori-induced Gastritis
(2009-11-13)Infection with the bacterium Helicobacter pylori is widespread throughout the world, and is associated with development of gastric and duodenal ulcer disease as well as gastric adenocarcinoma and mucosa associated lymphoid ...