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On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ... -
On chaperone co-operation in temporal and spatial protein quality control
(2021-03-29)In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks ... -
On community acquired infections requiring intensive care
(2015-01-07)Acute bacterial meningitis (ABM), influenza, and necrotizing soft-tissue infections (NSTIs) are diseases that in a short period of time can progress to become life threatening. Individuals with severe forms of these ... -
On gastrointestinal viral infections
(2022-11-10)Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. The aims ... -
On HIV in the elderly and vitamin B metabolism in HIV infection
(2022-01-17)The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the ... -
On HIV-1 latency and viral reservoirs
(2015-05-11)HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor ... -
On morbidity and mortality in novovirus infection
(2014-12-02)Norovirus causes epidemic gastroenteritis. The extent of excess mortality related to norovirus infections is not established and factors that influence the duration of viral shedding have not been determined. The aims of ... -
On the assessment and impact of liver fibrosis in patients with chronic hepatitis C
(2013-11-22)Hepatitis C virus (HCV) infection is associated with increased risk of severe liver damage, cirrhosis, and hepatocellular carcinoma (HCC). Despite pending highly efficacious HCV treatment, assessment of liver damage will ... -
On the Diagnosis and Management of Viral Respiratory Infections
(2010-05-28)Acute respiratory tract infections (ARTIs), are the most common infections in man, and represent a major global health burden. Viruses, most often causing a mild and self-limiting disease, yet with substantial morbidity ... -
On the epidemiology, clinical presentation and transmission of respiratory viral infections
(2020-03-05)Respiratory viral infections encompass a large heterogenous group of pathogens that constitute a major burden of disease globally. The various routes of transmission including airborne spread make them difficult to control. ... -
On the Origins of mobile Antibiotic Resistance Genes
(2021-05-17)Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is ... -
On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection
(2011-11-09)Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of ... -
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ... -
On the role of innate cell interactions in inflammation and leukemia
(2015-05-18)Inflammatory cells of the innate immune system launch rapid and powerful effector responses in the combat against infectious pathogens. However, these inflammatory mediators may cause excessive damage to the host and, ... -
On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia
(2022-02-14)Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. This ... -
On the role of signaling pathways in the pathogenesis of osteoarthritis
(2014-04-15)The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The ... -
On the stimulatory effect of microglial cells on angiogenesis
(2011-05-26)ABSTRACT Angiogenesis, the process by which new vessels sprout from pre-existing vessels, is fundamental to development, tissue growth and repair. The main aim of this thesis was to investigate the role of microglia on ... -
Oncogenic ALK signaling in neuroblastoma
(2017-05-15)Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, ... -
Origins of thyroid progenitors and tumor-initiating cells
(2018-05-14)The thyroid gland located in the anterior neck consists of two main cell types. First, the follicular cells that form the functional units, the follicles, in which thyroid hormones are produced and stored before release ... -
Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance
(2007-04-16)Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is ...