Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 159-178 of 346
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Identification and characterization of progenitor populations in the human adult heart
(2014-01-17)Traditionally, the heart has been regarded as a non-regenerative organ. During the last 10 years, this notion has been challenged. By 14C measurements, it was calculated that at the age of 50, about 45% of all cardiomyocytes ... -
Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
(2020-05-12)Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental ... -
Identification of stem cell factors - Novel protein-protein interactions and their functions
(2010-09-10)Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon ... -
Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses
(2023-11-22)Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies ... -
Immunization approaches and molecular signatures for mucosal immunity to primary and recurrent genital herpes
(2015-05-21)Genital herpes is most commonly caused by herpes simplex virus type 2 (HSV-2), and is a prevalent sexually transmitted infection worldwide. Despite numerous efforts, there is currently no licensed vaccine against the ... -
Immunofluorescence Investigation on Neuroendocrine Secretory Protein 55 (NESP55) in Nervous Tissues
(2008-03-31)The chromogranin family is a group of acidic, soluble, and heat-stable proteins widespread in various neuronal, neuroendocrine and endocrine tissues, where they are subcellullarly located in the secretory granules, ... -
Immunotherapy and immunosuppression in myeloid leukemia
(2018-11-12)Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis ... -
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
(2020-04-23)Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on ... -
Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection
(2015-01-30)Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. genetic variants ... -
Impact of NK cell repertoires on immunotherapy in acute myelod leukemia
(2017-11-08)Natural killer (NK) cells are lymphocytes endowed with cytotoxicity against aberrant cells, including transformed and virus-infected cells. NK cell function is dictated by a fine-tuned interplay between activating and ... -
In vitro toxicity testing using human pluripotent stem cell derivatives
(2016-11-23)Toxicity testing of chemicals, drug candidates, and food additives is in need of a change. The present methods, mainly consisting of animal models with their associated ethical concerns, are expensive, time-consuming, and ... -
Infant microbiota and short chain fatty acids - relation to lifestyle and effect on health
(2023-09-21)The commensal microbiota has both beneficial and negative effects on the host. It is a source of infectious and inflammatory microorganisms, but may also provide immune stimulation during a critical period during early ... -
Infections associated with percutaneous osseointegrated titanium implants for limb prostheses
(2017-10-26)Femoral amputation is a devastating event. Percutaneous, bone anchored prosthetic systems reduce problems associated with socket suspended prostheses, but the design is inherently vulnerable to infection. The aims of this ... -
Inflammatory mediator response to Gram-positive and Gram-negative bacteria in vitro and in middle ear infections
(2010-02-12)Based on the structure of the cell wall, bacteria are divided into Gram-positive and Gram-negative. While the cell wall of Gram-positive bacteria is thick, the cell wall of Gram-negatives is very thin and surrounded by an ... -
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ... -
Initiation of Mammalian Mitochondrial DNA Replication
(2014-04-04)Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required ... -
The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
(2010-01-19)Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, ... -
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
(2011-12-20)The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory ... -
Interpretation of diagnostic information given patient characteristics
(2006-10-20)The aim with this thesis was to describe, exemplify and develop theory for reference values and diagnostic tests, especially focusing on the variability between individuals. To facilitate interpretation of medical information ... -
Intestinal IgA synthesis: Localization and requirements for IgA class switch recombination
(2009-09-03)Production of IgA at mucosal surfaces is one of the most striking features of the mucosal immune system. Despite that IgA was first discovered in the 1950’s and secretory IgA described in gut secretions and breast milk ...