Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 118-137 of 345
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Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines
(2019-11-06)Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious ... -
General awareness of HIV, tuberculosis co-infections and the quality of life among patients with HIV in Xinjiang, in western China
(2015-05-22)Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are major public health problems, particularly in low and middle-income countries. China has the second-highest number of TB cases per year ... -
Genetic and molecular regulation of epithelial tube morphogenesis
(2006-09-29)Networks of epithelial tubes, such as the vertebrate lung, kidney and vascular system, enable transport of gases and nutrients to all tissues in the body. These tubes are built up by a single layer of polarized epithelial ... -
Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer
(2022-08-12)Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric ... -
Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription
(2015-09-16)Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors ... -
Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
(2009-03-06)Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response ... -
Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
(2007-11-12)Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack ... -
Genetic studies of children with mental retardation
(2013-02-20)Mental retardation (MR) is characterised by significant limitations in intellectual function and adaptive behaviour. It is estimated that MR affects up to 3% of the population in Europe. Patients with MR are an aetiologically ... -
Genetic studies of craniosynostosis with focus on syndromic forms
(2022-10-21)Craniosynostosis (CS) represents the premature closure of skull sutures and affects ~1 in 2500 children. Untreated CS can lead to significant complications in craniofacial and psychomotor development. The only treatment ... -
Genetic Studies of Psoriasis and Psoriatic Arthritis
(2008-02-08)Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop ... -
Genetic studies of the regulation of bone parameters and serum testosterone
(2018-05-29)Osteoporosis is a common disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased risk of fracture and represents a huge economic burden on health care systems. The ... -
Genetics and functions of innate-like lymphocyte subsets
(2007-09-21)The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the ... -
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ... -
Genomic and transcriptomic profiles in chronic hepatitis B infection
(2023-05-04)Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are ... -
Genomic instability and genetic heterogeneity in neuroblastoma tumours
(2017-11-03)Javanmardi, N., 2017, Genomic instability and genetic heterogeneity in neuroblastoma Department of Pathology and Clinical Genetics, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Sweden Neuroblastoma ... -
Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection
(2022-01-19)Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ... -
Genomic signatures in viruses
(2023-05-25)In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, ... -
Geographic and genetic diversity of hepatitis B
(2011-01-04)Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead ... -
The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
(2008-02-01)During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate ... -
Giant Cell Arteritis - Pathogenetic and Epidemiological Aspects
(2012-01-20)Giant cell arteritis (GCA) is a chronic inflammatory disorder of medium-size and large arteries which affects people aged 50 years or older with a female preponderance. The two different expressions of GCA are temporal ...