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Defining the pathways involved in spatial protein quality control in Saccharomyces cerevisiae
(2022-11-21)Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome ... -
Delineating cellular heterogeneity and organization of breast cancer stem cells
(2015-12-02)Breast cancer is characterized by a high degree of heterogeneity in terms of histological, molecular and clinical features, affecting disease progression and treatment response. The cancer stem cell (CSC) model suggests, ... -
Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88
(2007-12-21)The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during ... -
Dendritic cells and B cells in effector T cells decisions - promotion of antibody induction in lymphoid tissues or gut homing
(2018-05-14)Abstract CD4+ T cells are principal cells of the adaptive immune system, equipped with the ability to boost innate immune cells and aid B cells in the germinal centers. Every T cell clone carries a variable and unique T ... -
Deregulated epigenetics and cancer stem cells in brain tumours
(2022-05-11)Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, ... -
Derivation, Characterization and Differentiation of Feeder-Free Human Embryonic Stem Cells
(2010-05-17)Human embryonic stem cells (hESCs) are pluripotent cells with self-renewal ability, derived from the inner cell mass of a human blastocyst. They have the remarkable potential to develop into different cell types and can ... -
Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
(2013-11-11)The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of ... -
Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
(2007-08-22)Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are ... -
Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera
(2014-09-26)Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be ... -
Developmental origin and molecular regulation of vascular smooth muscle cells
(2008-11-18)Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. It has ... -
Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease
(2008-04-09)The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and ... -
DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning
(2008-11-24)131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. For ... -
Dual roles for hepatic lectin receptors in the clearance of chilled platelets
(2009-10-29)Platelets for transfusion are stored at room temperature because refrigerated platelets are cleared rapidly from circulation. Room temperature storage causes major inconveniences for blood banks and medical risks for ... -
Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis
(2007-11-06)The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. ... -
Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis
(2018-10-23)Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against ... -
Effects of antioxidant supplementation on cancer progression
(2018-05-18)Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ... -
Effects of biocides and metals on antibiotic resistance: a genomic and metagenomic perspective
(2017-01-10)Background and aim: There is a concern that biocides and metals can co-select for antibiotic resistance. The aim of this thesis is to enhance our understanding of the roles of antibacterial biocides (e.g. antiseptics, ... -
Embryonic ecdysone-induced gene expression and progression of organ morphogenesis
(2011-05-26)The formation of an epithelial organ requires a set of organ-specific gene programs that instruct parallel and successive developmental events. Still, it is unclear what are the core regulatory programs and how such programs ... -
Embryonic origin and development of thyroid progenitor cells. An experimental study focused on endoderm, EphA4 and Foxa2
(2010-06-04)The thyroid gland consists of two endocrine cell types, the follicular cells that produce the thyroid hormones T3 and T4 and the parafollicular C-cells that synthesize calcitonin. It is well-known that these cells have ... -
Epidemiologic studies on human enteric viruses in Cameroon
(2013-11-27)Enteric viruses are a diverse group of viruses that include those that multiply in the intestinal epithelium and cause gastroenteritis, and those that first multiply in the intestine and then spread to extra-intestinal ...