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The IL-23 axis and innate immunity in the airways

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Title: The IL-23 axis and innate immunity in the airways
Authors: Stockfelt, Marit
Issue Date: 8-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Inst of Medicine. Department of Internal Medicine and Clinical Nutrition
Parts of work: I. Hansson M, Silverpil E, Lindén A, Glader P. Interleukin-22 produced by alveolar macrophages during activation of the innate immune response. Inflammation Research 2013. Jun;62(6):561-9.

II. Silverpil E, Wright AK, Hansson M, Jirholt P, Henningsson L, Smith ME, Gordon SB, Iwakura Y, Gjertsson I, Glader P, Lindén A. Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation. Innate Immunity 2013 Oct; 19(5):479-92.

III. Smith ME*, Stockfelt M*, Tengvall S, Bergman P, Lindén A, Qvarfordt I. Endotoxin Exposure Increases LL-37 – but Not Calprotectin – in Healthy Human Airways. Journal of Innate Immunity. 2017. *Joint first authorship.

IV. Stockfelt M, Christenson K, Andersson A, Björkman L, Padra M, Sun J, Levänen B, Ganguly K, Asgeirsdottir H, Qvarfordt I, Bylund J and Lindén A. Neutrophil activation and associated cytokines before and after extravasation into the airways of smokers with and without COPD. Manuscript in preparation.
Date of Defence: 2017-12-01
Disputation: Fredagen den 1 december 2017, kl 9.00, Föreläsningssalen våning 3, Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: IL-23
Abstract: The Interleukin-23 (IL-23) axis is a communication system that integrates innate and adaptive immunity. When triggered by microbial stimuli, antigen presenting cells can secrete the cytokine IL-23, leading to the production of IL-17 and IL-22. These cytokines facilitate the recruitment of neutrophils that can eliminate microbes, but may also cause epithelial damage through extensive inflammation. At the same time, the IL-23 axis protects the epithelium through the production of antimicrobial p... more
ISBN: 978-91-629-0308-4 (print)
978-91-629-0309-1 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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