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Fibrinogen, platelet and factor XIII supplementation in cardiac surgery: In vitro and in vivo studies


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Title: Fibrinogen, platelet and factor XIII supplementation in cardiac surgery: In vitro and in vivo studies
Authors: Shams Hakimi, Caroline
E-mail: caroline.hakimi@gu.se
Issue Date: 2-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: Shams Hakimi C, Fagerberg Blixter I, Hansson EC, Hesse C, Wallén H, Jeppsson A. Effects of fibrinogen and platelet supplementation on clot formation and platelet aggregation in blood samples from cardiac surgery patients. Thromb Res. 2014; 134: 985-900.
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Shams Hakimi C, Singh S, Hesse C, Jeppsson A. Effects of fibrinogen and platelet transfusion on hemostasis in cardiac surgery patients with ongoing bleeding. In manuscript.

Shams Hakimi C, Carling MS, Hansson EC, Brisby H, Hesse C, Radulovic V, Jeppsson A. The effect of ex vivo factor XIII supplementation on clot formation in blood samples from cardiac and scoliosis surgery patients. Clin Appl Thromb Hemost. [Epub ahead of print]
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Hansson EC, Shams Hakimi C, Åström-Olsson K, Hesse C, Wallén H, Dellborg M, Albertsson P, Jeppsson A. Effects of ex vivo platelet supplementation on platelet aggregability in blood samples from patients treated with acetylsalicylic acid, clopidogrel, or ticagrelor. Br J Anaesth. 2014; 112: 570-575.
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Shams Hakimi C, Hesse C, Wallén H, Boulund F, Grahn A, Jeppsson A. In vitro assessment of platelet concentrates with multiple electrode aggregometry. Platelets. 2015; 26: 132-137.
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Date of Defence: 2017-11-24
Disputation: Fredagen den 24 november 2017, kl. 9.00, Förmaket, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: fibrinogen
platelets
factor XIII
platelet aggregation
clot formation
cardiac surgery
Abstract: Background: There is a high risk of bleeding complications in cardiac surgery. Fibrinogen and platelet concentrates are often used to treat perioperative bleeding, but there is little information about its efficacy. The overall aim of this thesis project was to study the effects of fibrinogen, platelet and factor XIII concentrates on markers of hemostasis in blood samples from cardiac surgery patients. Methods: Increasing doses of fibrinogen, platelets, and factor XIII were added to blood samp... more
ISBN: 978-91-629-0300-8 (Print)
978-91-629-0301-5 (PDF)
URI: http://hdl.handle.net/2077/52857
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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