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Expression of Tissue Antigens in Human Pluripotent Stem Cells and Alterations During Differentiation


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Title: Expression of Tissue Antigens in Human Pluripotent Stem Cells and Alterations During Differentiation
Other Titles: Potential application in regenerative medicine for treatment of terminal cell and organ failure
Authors: Karin, Säljö
E-mail: karin.saljo@vgregion.se
Issue Date: 24-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: Paper I. I. Barone A, Säljö K, Benktander J, Blomqvist M, Månsson JE, Johansson BR, Mölne J, Aspegren A, Björquist P, Breimer ME, Teneberg S. Sialyl-lactotetra, a novel cell surface marker of undifferentiated human pluripotent stem cells. Journal of Biological Chemistry 2014; 289, 18846-18859
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Paper II. Säljö K, Barone B, Vizlin-Hodzic D, Johansson BR, Breimer ME, Funa K, Teneberg S. Comparison of the glycosphingolipids of human-induced pluripotent stem cells and human embryonic stem cells. Glycobiology 2017; 27: 291-305.
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Paper III. Säljö K, Barone A, Mölne J, Rydberg L, Teneberg S, Breimer ME. HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and their Derivatives. Manuscript, submitted
Date of Defence: 2017-06-16
Disputation: Fredagen den 16 juni 2017, kl 9.00, Hörsal Arvid Karlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Pluripotent stem cells
Differentiation
Histo-blood group antigens
HLA
Tissue antigens
Sialyl-lactotetra
Cell surface antigens
Transplantation
Regenerative medicine
Abstract: The major limiting factor in the treatment of patients with end-stage organ failure is the insufficient number of human organs available for transplantation. An unlimited access to human cells, tissues and organs would also open up possibilities to treat several chronic diseases, such as diabetes, neurological and cardiovascular diseases, affecting millions of patients worldwide. Cells and tissues derived from human pluripotent stem cells (hPSC) could potentially fulfill these ambitions. However... more
ISBN: 978-91-629-0217-9 (Print)
978-91-929-0218-6 (Pdf)
URI: http://hdl.handle.net/2077/51884
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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