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Insulin-coated titanium implants - a potential therapy for local bone regeneration

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Title: Insulin-coated titanium implants - a potential therapy for local bone regeneration
Authors: Öhrnell Malekzadeh, Behnosh
Issue Date: 12-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Odontology. Department of Orthodontics
Parts of work: I. Malekzadeh B, Tengvall P, Öhrnell LO, Wennerberg A, Westerlund A. Effects of locally administered insulin on bone formation in non-diabetic rats. J Biomed Mater Res A. 2013 Jan;101(1):132-7.

II. Malekzadeh BÖ, Ransjo M, Tengvall P, Mladenovic Z, Westerlund A. Insulin released from titanium discs with insulin coatings - Kinetics and biological activity. J Biomed Mater Res B Appl Biomater. 2016 May 26.

III. Shchukarev A, Malekzadeh BÖ, Ransjö M, Tengvall P, Westerlund A. Surface characterization of insulin-coated Ti6Al4V medical implants conditioned in cell culture medium: An XPS study. Joural of Electron Spectroscopy and Related Phenomena. 2017 April;216:33-38.

IV. Malekzadeh BÖ, Erlandsson MC, Tengvall P, Palmqvist A, Ransjo M, Bokarewa MI, Westerlund A. Effects of locally administered insulin on bone formation in osteoporotic rats. Submitted.
Date of Defence: 2017-06-01
Disputation: Torsdagen den 1 juni 2017, kl 9.00, Föreläsningssal 3 (F3), Medicinaregatan 12E, Göteborg
Degree: Doctor of Philosophy (Odontology)
Publication type: Doctoral thesis
Keywords: Insulin
Abstract: Background: Insulin is a hormone that regulates glucose metabolism, however, it is also important for bone formation. The anabolic effect of insulin on bone could open up alternative therapies when it comes to local bone regeneration. However, this requires a method for local administration of insulin. Aim: The overall aim was to determine whether local administration of insulin, coated on a titanium surface has the potential to regenerate bone locally. Materials and methods: The surface chara... more
ISBN: 978-91-629-0149-3 (print)
978-91-629-0150-9 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för odontologi



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