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dc.contributor.authorJohnson, Mats
dc.date.accessioned2014-09-19T06:59:59Z
dc.date.available2014-09-19T06:59:59Z
dc.date.issued2014-09-19
dc.identifier.isbn978-91-628-9121-3
dc.identifier.urihttp://hdl.handle.net/2077/36752
dc.description.abstractAim: The overall aim of the thesis was to study alternative non-stimulant treatments for Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents and adults. Method: The thesis includes four studies referring to three different treatment trials. Study 1: Randomized double-blind placebo-controlled trial of Omega 3/6 fatty acids (Equazen eyeq) treatment of ADHD in children and adolescents. Study 2: Changes in plasma fatty acid profiles in the Omega 3/6 trial, and comparison with treatment response. Study 3: One year trial of efficacy and safety of the non-stimulant medication atomoxetine in adults with ADHD. Study 4: Study of the effectiveness of the cognitive-behavioural model “Collaborative Problem Solving” (CPS) in children with ADHD and Oppositional Defiant Disorder (ODD). Results: The overall group results of Study 1 were negative, but clinical response was seen in subgroups such as those with ADHD inattentive subtype, Developmental Coordination Disorder (DCD), and reading-writing disorder. Study 2 findings suggested that clinical response to Omega 3/6 was associated with plasma fatty acid changes, especially with reduction of the n-6/n-3 ratio. Study 3 showed a moderate effectiveness of atomoxetine after 10 weeks in adults with ADHD, but the longer-term compliance to treatment was poor. In study 4 CPS showed promise in reducing problem behaviours in children with ADHD and ODD, and children with severe ADHD symptoms may be improved by combining CPS and ADHD medication. Conclusions: The trials of non-stimulant treatments included in this thesis showed some promising results and suggested directions for future research and study designs.sv
dc.language.isoengsv
dc.relation.haspartJohnson M, Östlund S, Fransson G, Kadesjö B, Gillberg C (2009). Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder. A Randomized Placebo-Controlled Trial in Children and Adolescents. Journal of Attention Disorders 12, 394–401. ::doi:: 10.1177/1087054708316261sv
dc.relation.haspartJohnson M, Månsson J-E, Östlund S, Fransson G, Areskoug B, Hjalmarsson K, Landgren M, Kadesjö B, Gillberg C (2012). Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. ADHD Attention Deficit and Hyperactivity Disorders 4, 199-204. ::doi:: 10.1007/s12402-012-0084-4sv
dc.relation.haspartJohnson M, Cederlund M, Råstam M, Areskoug B, Gillberg C (2010). Open-Label Trial of Atomoxetine Hydrochloride in Adults with ADHD. Journal of Attention Disorders 13, 539-545. ::doi:: 10.1177/1087054709332372sv
dc.relation.haspartJohnson M, Östlund S, Fransson G, Landgren M, Nasic S, Kadesjö B, Gillberg C, Fernell E (2012). Attention deficit/ hyperactivity disorder with oppositional defiant disorder in Swedish children – an open study of Collaborative Problem Solving. Acta Paediatrica 101, 624- 630. ::doi::10.1111/j.1651-2227.2012.02646.xsv
dc.subjectAttention Deficit Hyperactivity Disordersv
dc.subjectOmega 3/6sv
dc.subjectPlasma Fatty Acidssv
dc.subjectAtomoxetinesv
dc.subjectCollaborative Problem Solvingsv
dc.titleNon-stimulant interventions in ADHDsv
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailmats.johnson@gnc.gu.sesv
dc.type.degreeDoctor of Philosophy (Medicine)sv
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academysv
dc.gup.departmentInstitute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistrysv
dc.gup.defenceplaceFredagen den 3 oktober 2014, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3sv
dc.gup.defencedate2014-10-03
dc.gup.dissdb-fakultetSA


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