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Experimental and population-based studies on colorectal cancer - Thymidine phosphorylase as a potential biomarker

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Title: Experimental and population-based studies on colorectal cancer - Thymidine phosphorylase as a potential biomarker
Authors: Bexe Lindskog, Elinor
Issue Date: 5-Sep-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Elinor Bexe Lindskog, Yvonne Wettergren , Elisabeth Odin , Bengt Gustavsson, Kristoffer Derwinger Thymidine phosphorylase gene expression in stage III colorectal cancer Clin Med Insights Oncol. 2012; 6: 347-353

II. Kristoffer Derwinger, Elinor Bexe Lindskog, Erik Palmqvist, Yvonne Wettergren Changes in thymidine phosphorylase gene expression related to treatment of rectal cancer Anticancer Res. 2013; 33(6): 2447-51

III. Elinor Bexe Lindskog, Kristoffer Derwinger, Bengt Gustavsson, Peter Falk, Yvonne Wettergren Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer BMC Clin Pathol. 2014; 14: 25

IV. Elinor Bexe Lindskog, Katrín Ásta Gunnarsdóttir, Kristoffer Derwinger, Yvonne Wettergren, Bengt Glimelius, Karl Kodeda A population-based cohort study on adherence to practice guidelines for adjuvant chemotherapy in colorectal cancer Submitted for publication
Date of Defence: 2014-09-26
Disputation: Fredagen 26 september 2014 kl 09.00, stora aulan, centralkliniken, Sahlgrenska Universitetssjukhus/Östra.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: colorectal cancer
thymidine phosphorylase
chemotherapy, adjuvant
biological markers
practice guidelines
Abstract: Background: Colorectal cancer (CRC) is one of the most common malignancies, and the only reliable treatment option for cure is surgery. Method: Quantitative real-time polymerase chain reaction was used to analyze the gene expression of the enzyme thymidine phosphorylase (TP), which was related to prognostic factors (paper I, n=254), evaluated as a predictive factor (paper III, n=125), and assessed by change of treatment (paper II, n=28). Data from the Swedish Colorectal Cancer Registry were re... more
ISBN: 978-91-628-9086-5 (tryckt)
978-91-628-9092-6 (pdf)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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