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Receptor Cross-talk and Neutrophil Function


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Title: Receptor Cross-talk and Neutrophil Function
Authors: Granhagen Önnheim, Karin
E-mail: karin.onnheim@rheuma.gu.se
Issue Date: 8-May-2013
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Rheumatology and Inflammation Research
Parts of work: I. Önnheim K, Bylund J, Boulay F, Dahlgren C, Forsman H. Tumour necrosis factor (TNF)-alpha primes murine neutrophils when triggered via formyl peptide receptor-related sequence 2, the murine orthologue of human formyl peptide receptor-like 1, through a process involving the type I TNF receptor and subcellular granule mobilization. Immunology. 2008 Dec;125(4):591-600
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II. Forsman H, Salomonsson E, Önnheim K, Karlsson J, Björstad A, Leffler H, Bylund J, Karlsson A, Dahlgren C. The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist.Glycobiology. 2008 Nov;18(11):905-12.
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III. Forsman H*, Önnheim K*, Andréasson E, Christenson K, Karlsson A, Bylund J, Dahlgren C Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. PLoS One. 2013;8(3):e60169
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IV. Önnheim K, Christenson K, Amirbeagi F, Martner A, Bylund J, Dahlgren C, Forsman H ATP triggers reactivation of desensitized formyl peptide receptors: A novel receptor cross talk mechanism regulates phagocyte superoxide anion production In manuscript
Date of Defence: 2013-05-23
Disputation: Torsdagen den 23 maj 2013, kl 9.00, Föreläsningssalen Guldhedsgatan 10, vån 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: FPR
receptor cross-talk
Neutrophils
Phagocytes
Abstract: The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation, to sites of infection and inflammation, is dependent upon a gradient of chemoattractants released from cells at the inflamed area. The chemoattractants, including formyl peptides, are recognized by G-protein coupled chemoattractant receptors (GPCRs) present on the neutrophil surface. Activation of GPCRs in neutrophils mediates chemotaxis, but also granule mobilization and the generation of reacti... more
ISBN: 978-91-628-8669-1
URI: http://hdl.handle.net/2077/32379
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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