Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
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Superparamagnetic iron oxide for sentinel lymph node biopsy
(2024-04-18)Superparamagnetic iron oxide nanoparticles (SPIO), used as a tracer for sentinel lymph node (SLN) detection, offer several logistical benefits over the standard method using radioactive technetium-99m and blue dye. The ... -
Relationship of Surgical Technique and Bony Morphology on Anterior Cruciate Ligament (ACL) Failure- Effect of Surgical Volume on Surgical Technique
(2024-04-15)Anterior cruciate ligament (ACL) injuries are becoming increasingly common and can have a detrimental effect on patients and their activities. Anatomic ACL reconstruction remains the gold standard for treatment. While ... -
Endovascular repair of aortic disease. Clinical and radiological outcomes
(2024-04-11)Background: Endovascular repair of aortic disease has improved but long-term outcome is questioned. Aims: To evaluate radiological and clinical outcome of endovascular aortic repair. Specifically: I. To evaluate if expansion ... -
lnfluence of stem design on Total Hip Arthroplasty. Clinical and radiological assessment based on randomized controlled trials and register data
(2024-04-09)Since the 1960s, total hip arthroplasty has revolutionized the care of patients with end-stage osteoarthritis. Results after surgery using contemporary implants are usually good. Nevertheless, new implants are constantly ... -
Perinatal brain damage-phagoptosis and neuroprotection
(2024-03-27)Background: Neonatal encephalopathy is a serious outcome in term infants affecting 1-2/1000 live births and is often caused by perinatal hypoxia-ischemia (HI). However, brain injury is multifactorial and infection in the ... -
Long-term Bowel and Stoma Function Following Colorectal Cancer Surgery
(2024-03-25)Aim: The aim of this thesis was to explore bowel and stoma function following colorectal cancer surgery, to investigate associated distress and identify possible risk factors. Methods: Papers I, II, and IV were based on ... -
On incidence, diagnostic algorithms and in-depth characterisation of thyroid cancer
(2024-03-20)Background: Thyroid cancer (TC) incidence has increased dramatically. Overzealous detection of subclinical disease is the most common explanation. However, whether the higher rate of diagnosis of subclinical disease might ... -
Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Melanoma surgery in the era of modern immunotherapy
(2024-01-30)Recent advances in immuno-oncology have led to a paradigm shift in the treatment of advanced cutaneous melanoma. The aim of this thesis is to investigate the role of surgery in the management of melanoma in this modern era ... -
Psychosocial Aspects of Dravet Syndrome
(2024-01-15)Dravet syndrome (DS) is a developmental and epileptic encephalopathy, associated with significant neurodevelopmental comorbidity. The aims of this population-based study were to describe the epidemiology, genetics, mortality, ... -
Uterine Tissue Engineering: Translational approaches using animal models
(2023-12-14)Recent advancements, such as uterus transplantation (UTx), have led to groundbreaking solutions for complete uterine dysfunction. Yet, there are inherent risks and limitations, including challenges of sourcing compatible ... -
Femoral shaft fractures in children and adolescents; stability, residual deformity and recovery of physical function
(2023-12-14)Femoral shaft fracture is the most common injury requiring hospital admission among children. The limited number of studies makes it challenging to provide accurate prognosis for recovery after femoral shaft fractures in ... -
lncidence of Colorectal Cancer and Comparisons of Outcomes after Minimally Invasive and Open Surgery
(2023-12-07)Aim: Surgery remains the mainstay of treatment for colorectal cancer. The aim of this thesis was to determine the overall incidence of colorectal cancer in Sweden over time and to evaluate surgical treatment comparing ... -
lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation
(2023-11-24)Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. ... -
Acute Achilles tendon rupture: The impact of physiological and psychological factors on function and return to activity
(2023-11-17)Unfortunately, there is no guarantee of a full return to physical activity after an Achilles tendon rupture. About 20% of those who sustain the injury do not return to their previous level of physical activity. Although ... -
Risk Factors for Diabetic Ketoacidosis in Children
(2023-11-10)Background: Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes. It is preventable if timely administration of sufficient amounts of insulin is initiated. A large proportion of children are ... -
Ultrasound and molecular biomarkers for prediction of preterm delivery in different risk groups of singleton pregnancies
(2023-11-06)Ultrasound and molecular biomarkers for prediction of preterm delivery in women with a singleton pregnancy Tove Wikström Department of Obstetrics and Gynecology, Institute of Clinical Sciences Sahlgrenska Academy, ... -
Morbidity and mortality following standardised perioperative management of patients operated with acute abdominal surgery in a high-risk emergency setting
(2023-11-06)Patients suffering from acute pathology in the abdomen is common throughout the world and surgical intervention can often be necessary. Those who are most seriously ill need an acute management with major abdominal surgery, ... -
Diffusion MRI: Aspects of Reproducibility and Novel Segmented 2D and 3D Approaches for Higher Resolution and Geometric Fidelity
(2023-11-06)Diffusion-weighted imaging (DWI) is a very useful tool for non-invasive imaging and clinical investigation of the human body. It provides data of the water diffusion process. Applied to biological tissues in a clinical ... -
Advancements in DSC and BOLD perfusion imaging: Acquisition, analysis and clinical application
(2023-10-31)This thesis is focused on perfusion MRI techniques and topics related to image acquisition, analysis and clinical applications. The first half of the thesis is focused on dynamic susceptibility contrast (DSC) MRI, a technique ...