Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Browse by
Recent Submissions
-
The role of sodium salicylate as a virulence inhibitor for soft tissue infections
Approximately 2% of the total population will suffer from chronic wounds during their lifetime. These wounds can last for years and are associated with considerable patient suffering and large socioeconomic costs. ... -
Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods
Background: Cystic Fibrosis (CF) is an inherited progressive disease that causes severe damage to the airways and other organs of the body. Many methods are available to track CF lung disease but longitudinal data are ... -
Proximal and distal humeral fractures. Outcome of primary arthroplasty
This thesis deals with both proximal humeral fractures and elbow injuries, especially distal humeral fractures. The main focus is difficult fractures in the elderly. Few randomized controlled trials (RCTs) are available. ... -
lntestinal health after pelvic radiotherapy - towards understanding persisting pathophysiological mechanisms
Pelvic cancer survivors struggle with life-long symptoms caused by radiotherapy. Many pelvic cancer survivors live with a constant fear of leaking faeces and the need to always have a toilet within reach. Some of these ... -
Optimisation of radionuclide therapy by reduction of normal tissue damage
Background:177Lu-octreotate is used to treat patients with neuroendocrine tumours (NETs) often resulting in prolonged life and better quality of life, but is today seldom a cure for these patients. Optimisation of ... -
Gallstone-related symptoms and quality-of-life in patients undergoing gallstone surgery - The Gothenburg Gallstone Questionnaire (GGQ24)
Background: Patients with symptomatic gallstone disease can present with years of intermittent suffering or acute complicated disease. The only definitive cure is surgery. Registering both surgical and patient reported ... -
Metopic synostosis - surgical results and perinatal aspects
Metopic synostosis (MS) is the second most common type of craniosynostosis (CS). This thesis aimed to evaluate surgical results in children operated for MS, their perinatal outcomes and potential etiological risk ... -
Diving and the brain
Abstract Introduction There are reports that long-term diving is associated with cognitive impairments. This raises the question if diving itself is harmful to the brain in the absence of decompression sickness ... -
Centralized Ovarian Cancer Care - Complications, Costs and Survival
Background: Ovarian cancer is often diagnosed at advanced stages, and its mortality is high. Surgical treatment of advanced ovarian cancer strives toward complex primary debulking surgery (PDS), aiming for complete ... -
Human papillomavirus infection and preterm delivery
Background: Persistent human papillomavirus (HPV) infection causes cervical intraepithelial neoplasia (CIN). Excisional treatment of CIN has been linked to increased risk of preterm delivery (PTD). The specific mechanism ... -
Valvular aortic stenosis in children. Outcome, physical activity and health-related quality of life
Introduction: Isolated valvular aortic stenosis (VAS) accounts for 3–5% of congenital heart disease and presents with a wide spectrum of severity. Critical VAS in the neonate is the most severe form, fatal in the absence ... -
Mild primary hyperparathyroidism - Long-term effects of parathyroidectomy versus observation - with emphasis on skeletal outcomes
Background: The majority of patients with primary hyperparathyroidism (PHPT) in developed countries today present with no obvious symptoms, i.e. the mild form of the disease. As the only curative treatment is parathyroidectomy ... -
Curatively Intended Treatment of Colorectal Liver Metastases - Patient, Primary and Metastatic Pattern as Prognostic Factors
Background: Resection and/or ablation of colorectal liver metastases (CRLM) is increasingly common and long-term results are improving. In this thesis prognosis of CRLM is studied in a wide perspective, with focus on common ... -
On the biological response to different biomaterials under normal and irradiated conditions
There are several challenges when introducing an implant into a host. Concerning soft tissues, major complications are fibrosis and capsule contracture, whereas for bone, failure of osseointegration may occur. In addition ... -
Revision anterior cruciate ligament reconstruction - current evidence, predictors and outcome
Despite extensive research in the field of anterior cruciate ligament (ACL) reconstruction, primary ACL reconstruction failure and a high re-rupture rate remain a problem. Far too many patients experience a second devastating ... -
lmprovement in perioperative care of the day case patient; logistics and quality of care.
(2022-02-23)Background: The “Day surgery concept” is increasing and nowadays numerous of surgical procedures in patients of all ages, with different comorbidities are performed as day case surgery. Day surgery (DS) is a process; not ... -
Promoting the Clinical Relevance of 3D Bioprinting
(2022-02-03)This thesis focuses on the development of methodologies enabling the reconstruction of autologous, functional, and long-term-stable cartilage-like tissue using 3D bioprinting technology and animal experiments. The stability, ... -
Pelvic floor dysfunction in nulliparous women
(2022-01-18)Background: Pelvic floor dysfunction (PFD) is a public health problem affecting millions of women worldwide. In addition to personal suffering, it also creates an economic burden for health care systems and society. Parity ... -
Bioabsorbable Screws for Pelvic Osteotomies in Children
(2022-01-07)Multiple conditions, with developmental dysplasia of the hip being a prime example, affect the congruity of the pediatric hip joint. A Salter osteotomy (SO) or a triple pelvic osteotomy (TPO) can be used to address suboptimal ... -
On the biological behavior of barrier membranes: implications for Guided Bone Regeneration. Clinical and Experimental studies
(2021-12-21)There is a continuous development of bone augmentation solutions to meet the rising demand for effective dental implant rehabilitations. One of the most used techniques is Guided Bone Regeneration (GBR). Although successful ...
RSS 1.0