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Targeting Myc-driven tumours - BETing on ATR
(2016-03-17)
Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell ...
Measurement of outcome in lumbar spine surgery
(2020-04-02)
BACKGROUND. The purpose of elective lumbar spine surgery is mainly to reduce pain and to improve physical function and quality of life. The quality and results of the interventions are monitored in the Swedish spine register, ...
Anterior Cruciate Ligament Reconstruction; Randomized Trials, Register Studies and Experimental Analysis of Knee Laxity
(2013-05-02)
The aim of this thesis was to evaluate the short- and mid-term outcome of Anterior Cruciate Ligament (ACL) reconstruction, with special emphasis on surgical techniques, type of autograft and the influence of gender, using ...
Arthroscopic Bankart reconstruction using different absorbable tacks. The clinical results, radiographic findings and effect on calcaneal bone mineral
(2013-11-04)
ABSTRACT
The aim of the thesis was to explore the clinical and radiographic results after post- traumatic anterior shoulder instability treated with arthroscopic Bankart surgery using absorbable tacks with different ...
Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
(2014-02-10)
The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to ...
Virtual Reality Simulations and Interventional Radiology
(2007-03-26)
INTRODUCTION: Use of virtual reality (VR) simulators in endovascular interventional education has become increasingly popular yet many questions surrounding this nascent technology remain unanswered. While progress has ...
Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
(2015-05-18)
ABSTRACT
Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene ...
Femoroacetabular impingement syndrome. Trends and outcomes after arthroscopic treatment in the general and athlete population
(2021-08-18)
Femoroacetabular impingement syndrome (FAIS) is a common cause of hip pain in the young and athletic population. The diagnosis - FAIS - is based on a triad of symptoms, clinical evaluation and radiographic signs. The ...
The oesophageal mucosa in reflux disease - endoscopic appearance and tissue structure
(2008-01-18)
Gastro-oesophageal reflux disease (GORD) is very common in especially the western world. The cardinal symptoms are heartburn or regurgitations and are caused by the reflux of noxious compounds from the stomach/duodenum to ...
Assessment of neurological prognosis after cardiac arrest – clinical and neurophysiological aspects
(2021-04-06)
Background: Post-resuscitation care after cardiac arrest in adults includes targeted temperature management (TTM) to mitigate secondary brain injury. The recommended target temperature is between 32°C and 36°C after a ...