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Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
(2014-02-10)
The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to ...
Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
(2015-05-18)
ABSTRACT
Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene ...
Aspects on the management of patients with eosinophilic esophagitis
(2015-05-11)
Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the ...
Bladder pain syndrome/interstitial cystitis. Studies on classic BPS/IC, ESSIC type 3C, with special reference to the role of nitric oxide
(2012-11-09)
Patients presenting with symptoms of Bladder Pain Syndrome (BPS) are challenging to the urologist. Previously known as Interstitial Cystitis (IC), this syndrome has been extensively debated and investigated. IC mainly ...
The use of fibrinogen in cardiac surgery patients-clinical and experimental studies
(2019-10-30)
BACKGROUND Cardiac surgery with cardiopulmonary bypass impairs hemostasis due to hemodilution and consumption of platelets and coagulation factors, such as fibrinogen. The aim of this thesis was to study the role of ...
Human embryonic stem cells for bone engineering applications
(2011-05-26)
The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and ...
Screening for Hypertrophic Cardiomyopathy in Asymptomatic Children and Adolescents. Psychosocial consequences and impact on quality of life and physical activity.
(2011-10-11)
The aim of this thesis was to describe the consequences of being diagnosed with hypertrophic cardiomyopathy (HCM) while being asymptomatic, taking into consideration psychosocial effects and medical aspects of diagnosis ...
Intravoxel incoherent motion modeling - Optimization of acquisition, analysis and tumor tissue characterization
(2018-09-13)
Intravoxel incoherent motion (IVIM) analysis provides a means to obtain information on diffusion and perfusion from a single MRI sequence. The measurements are completely noninvasive and the results have been shown to be ...
Three-dimensional guidance for Endovascular Aortic Repair
(2017-09-25)
Image fusion (IF) of preoperative computed tomography (CT) with intraoperative cone-beam CT (CBCT) is a potentially powerful tool for guidance during endovascular aortic repair (EVAR). It may improve intraoperative anatomic ...
Polycystic ovary syndrome - morphologic and dynamic evaluation by magnetic resonance imaging
(2013-05-10)
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder, affecting up to 15% of women of reproductive age. The syndrome is characterized by oligo-anovulation, hyperandrogenism and polycystic ovaries. What constitutes ...