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Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions
(2015-09-10)
This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, ...
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)
The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ...
Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
(2009-11-26)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development ...
Influence of inflammation and of stage of lung development on the development of neonatal lung injury
(2010-11-26)
Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological ...
Surgery and Ischemia in Uterus Transplantation. Studies in various experimental models.
(2007-09-10)
The use of transplantation to enhance quality of life is a growing clinical field that also includes transplantation of reproductive organs. Transplantation of the uterus has been suggested as future method to treat uterus ...
Cyclooxygenase activity and tumor progression
(2008-09-26)
Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as ...
Neurochemical and cognitive aftermaths of surgery - studies on short- and long-term effects of surgery and anesthesia
(2020-10-01)
Background: Each year, around the world, more than 230 million patients have surgery. Improvements in healthcare have resulted in older and sicker patients undergoing surgical interventions. As a result, surgical safety ...
Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
(2014-05-09)
Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate ...
Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia
(2015-11-26)
Cancer anorexia-cachexia syndrome (CACS) develops in response to tumor-host biochemical interactions. A loss of appetite (anorexia) and increased metabolism results in a progressive wasting of adipose and skeletal muscle ...