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Human embryonic stem cells for bone engineering applications
(2011-05-26)
The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and ...
Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
On the influence of micro-and macroscopic surface modifications on bone integration of titanium implants
(2007-01-31)
Background: Osseointegrated titanium implants are routinely used in clinical denstistry
as anchorage units for dental prostheses. Although the overall clinical results are good,
there are clinical situations when an ...
On a novel technique for preparation and analysis of the implant surface and its interface to bone
(2008-06-13)
The ultrastructural and biomechanical properties of the bone-implant interface are important factors for implant performance. For further understanding of the osseointegration process novel tools enabling analysis of the ...
Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
(2014-05-09)
Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate ...
Regenerative effects of mesenchymal stem cell-derived exosomes
(2019-02-06)
Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has ...
A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
(2016-05-13)
The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, ...
The percutaneous implant. The effects of design, host site and surgery on the tissue response
(2018-02-14)
This research project focuses on the multiple challenges associated with implants that breach the skin. The role of device design, host site, and surgical approach on tissue response and outcome are evaluated, experimentally ...
Osteocytes as indicators of bone quality - multiscale structure-composition characterisation of the bone-implant interface
(2017-09-01)
By virtue of certain design features, bone anchored metal implants can be made to elicit a strong initial osteogenic response, i.e., the amount of bone formed. While quantitative differences are often lost at longer follow ...
The effect of tobacco exposure on bone healing and the osseointegrationof dental implants
(2017-05-17)
Background: The mechanisms behind the impact of smoking on
osseointegration are not fully understood. Aim: To correlate the clinical and
molecular aspects of osseointegration in smokers compared with non-smokers.
Methodology: ...