Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 552-571 of 634
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Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment
(2016-03-18)Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable ... -
Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
(2018-11-06)ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, ... -
Targeting Myc-driven tumours - BETing on ATR
(2016-03-17)Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell ... -
Testosterone, 17β-estradiol and pubertal growth
(2014-05-20)Background and aims: It is well established that the interaction of sex steroids with the growth hormone (GH)/ insulin-like growth factor 1 (IGF-1) axis is of major importance in children for normal pubertal growth. However, ... -
Thalidomide Embryopathy - Orthopaedic aspects. Degenerative changes and quality of life at age 45
(2016-11-18)In the late 1950s and early 1960s, a sudden peak was seen among children with different, severe malformations, caused by the intake of the drug thalidomide during pregnancy. Among other featured malformations, so-called ... -
The bone cement implantation syndrome - epidemiology, pathophysiology and prevention
(2019-09-18)Bone cementation implantation syndrome (BCIS) has significant morbidity and mortality for patients who are undergoing cemented hip hemiarthroplasty or arthroplasty. The aim of this thesis is to contribute with information ... -
The Clinical Importance Of Anti-Endothelial Cell Antibodies In Chronic Kidney Dysfunction And Organ Transplantation
(2015-06-15)The endothelium is the thin layer of cells that lines the interior surface of blood vessels and is the first site of contact between immune cells and tissues. Therefore, alterations at the level of the endothelium are ... -
The clinical utility of patient-reported outcome measures in total hip replacement and lumbar spine surgery
(2018-05-15)Background: Beginning in the late 1990s, the Swedish Hip Arthroplasty Register (SHAR) and the Swespine have successfully implemented programs to collect patient-reported outcomes measures (PROMs). The use of PROMs has ... -
The Diabetic Foot - assessment and assistive devices
(2017-02-28)Foot ulcers are a serious complication in diabetes and the most common factor leading to lower extremity amputation. The Swedish National Guidelines for Diabetes Care recommend an annual foot check for all 400,000 patients ... -
The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies
(2020-05-18)Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of LAs on cancer cells ... -
The effect of tobacco exposure on bone healing and the osseointegrationof dental implants
(2017-05-17)Background: The mechanisms behind the impact of smoking on osseointegration are not fully understood. Aim: To correlate the clinical and molecular aspects of osseointegration in smokers compared with non-smokers. Methodology: ... -
The epidemiology of cardiac arrest - In-hospital risk assessment, treatment and outcome
(2020-10-12)AIM: To describe and analyse sudden cardiac arrest, both in hospital and out of hospital, from an epidemiological perspective, by early prediction, by comparing changes over time in relation to aetiology, characteristics, ... -
The impact of signaling factors on intervertebral disc degeneration and regeneration - studies on disc and mesenchymal stem cells from chronic low back pain patients
(2020-05-19)INTRODUCTION: Chronic low back pain (LBP) is associated with degeneration of the intervertebral discs (IVDs). Increased expressions of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and matrix metalloproteinases ... -
The importance of lifestyle factors for the outcome of gynecological surgery
(2017-04-06)Background: Hysterectomy (HT), urinary incontinence- (UI) and pelvic organ prolapse (POP) surgery are common surgical procedures in women with benign disorders and more than 16 000 procedures are performed annually in ... -
The influence of match events on injury incidence during male World Cup football - Epidemiological studies and video analysis of injuries
(2015-01-09)The aim of this thesis was to assess the effect of game-related match events on the variation in injury incidence in top-level male football. Specifically, the primary aims were to investigate: (1) a possible relationship ... -
The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
(2014-05-14)Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective ... -
The percutaneous implant. The effects of design, host site and surgery on the tissue response
(2018-02-14)This research project focuses on the multiple challenges associated with implants that breach the skin. The role of device design, host site, and surgical approach on tissue response and outcome are evaluated, experimentally ... -
The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
(2015-08-18)Bone metastasis of a predominantly osteoblastic (sclerotic) nature is the outcome for the vast majority of patients with castration-resistant prostate cancer (CRPC). Pathologically, osteoblastic tumors are characterized ... -
The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease
(2012-11-30)The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is being also locally expressed and active in several organs ... -
The role of head size in total hip arthroplasty - Dislocation, wear and cup stability
(2021-02-24)Large heads are used in total hip arthroplasty, with the aim of reducing the risk of dislocation, but there are concerns related to polyethylene wear, corrosion and cup loosening. Paper I is an observational study that ...