Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 422-441 of 556
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Radiation-induced dysphagia in head and neck cancer - risk structures and methodological aspects
(2019-08-19)Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating ... -
Radiobiological effects of alpha-particles from Astatine-211: From DNA damage to cell death
(2011-05-26)ABSTRACT In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an -particle emitting radionuclide, promising ... -
Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
(2015-04-08)Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. 211At ... -
Radiological evaluation of esophageal function in dysphagia with special emphasis on achalasia
(2008-10-03)In idiopathic achalasia, degeneration of the inhibitory innervation of the esophageal smooth muscle results in absence of primary peristalsis and in incomplete relaxation of the lower esophageal sphincter (LES). All ... -
Radiotherapy and voice rehabilitation in laryngeal cancer: Effects on quality of life and voice function
(2015-02-27)The overall aim of the thesis was to describe the effects of radiotherapy following laryngeal cancer on health-related quality of life (HRQL) and voice function as well as to assess the efficiency of voice rehabilitation. ... -
Recruitment of small size lungs - experimental studies
(2012-05-15)Background: Patients - both children and adults - undergoing anesthesia and mechanical ventilation rapidly develop atelectasis. Even more severe problems occur in patients with acute lung injury/acute respiratory distress ... -
Rectal Cancer and Quality of Life. Aspects on Communication and Patient Education
(2021-03-16)Background This thesis reports the results of three studies based on a pro-spective cohort study of an unselected population of patients with rectal cancer, and one study based on an exploratory study of a new patient ... -
Recurrent unexplained first-trimester miscarriage. Effects of acetylcalicylic acid, platelet aggregation and thyroid disease
(2019-10-18)Recurrent unexplained first-trimester miscarriage. Effects of acetylsalicylic acid, platelet aggregation and thyroid disease. Lennart Blomqvist, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, ... -
Regenerative effects of mesenchymal stem cell-derived exosomes
(2019-02-06)Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has ... -
Regional fluxes of tissue plasminogen activator in porcine endotoxemia
(2007-10-30)Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator ... -
Rejection and Immunosuppression at Uterus Transplantation: an experimental study in rodents.
(2009-12-01)Uterus transplantation is developed as a possible treatment for patients with absolute uterine factor infertility. There has been one attempt to transplant a human uterus, which however failed and more basic research is ... -
Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy
(2009-04-06)BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) ... -
Renal artery stenosis. Aspects of diagnosis and endovascular treatment.
(2018-03-23)Background. Renal artery stenosis (RAS) becomes haemodynamically significant when it reduces the arterial pressure below the threshold for autoregulation of renal perfusion. Physiological responses to reduced renal perfusion ... -
Renal denervation in patients with resistant hypertension
(2018-02-05)BACKGROUND Catheter-based renal denervation (RDN) is a potential modality in the treatment of patients with resistant hypertension (RH). The biological effects of RDN are not fully comprehended and studies examining its ... -
Renal function after transplantation of the liver and intestine
(2010-01-27)Background: Chronic kidney disease (CKD) after liver (LT) or intestinal (IT) transplantation may decrease patient survival. Calcineurin inhibitors (CNI) play a major role in its development. Aims: Describe long term renal ... -
Renal perfusion, function and oxygenation after major surgery and in septic shock
(2017-11-24)Acute kidney injury (AKI) is a common and dreaded complication to severe illness and major surgery, with major impact on mor- bidity and mortality. The aim of this doctoral thesis was to increase the knowledge on renal ... -
Respiratory and esophageal morbidity in adults with repaired esophageal atresia
(2014-03-24)Background: Esophageal atresia (EA) often leads to persistent esophageal and respiratory symptoms, as well as impaired esophageal and lung function in adulthood. The reasons for this, and the connections between symptoms ... -
Revision anterior cruciate ligament reconstruction - current evidence, predictors and outcome
Despite extensive research in the field of anterior cruciate ligament (ACL) reconstruction, primary ACL reconstruction failure and a high re-rupture rate remain a problem. Far too many patients experience a second devastating ... -
Robotic Surgery for Endometrial Cancer
(2021-04-16)Endometrial cancer (EC) is the most common gynecological malignancy. A large proportion of patients present with the risk factors high age and obesity, which puts them at increased risk when undergoing surgery. The last ... -
The role of sodium salicylate as a virulence inhibitor for soft tissue infections
Approximately 2% of the total population will suffer from chronic wounds during their lifetime. These wounds can last for years and are associated with considerable patient suffering and large socioeconomic costs. ...