Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 563-582 of 632
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The importance of lifestyle factors for the outcome of gynecological surgery
(2017-04-06)Background: Hysterectomy (HT), urinary incontinence- (UI) and pelvic organ prolapse (POP) surgery are common surgical procedures in women with benign disorders and more than 16 000 procedures are performed annually in ... -
The influence of match events on injury incidence during male World Cup football - Epidemiological studies and video analysis of injuries
(2015-01-09)The aim of this thesis was to assess the effect of game-related match events on the variation in injury incidence in top-level male football. Specifically, the primary aims were to investigate: (1) a possible relationship ... -
The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
(2014-05-14)Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective ... -
The percutaneous implant. The effects of design, host site and surgery on the tissue response
(2018-02-14)This research project focuses on the multiple challenges associated with implants that breach the skin. The role of device design, host site, and surgical approach on tissue response and outcome are evaluated, experimentally ... -
The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
(2015-08-18)Bone metastasis of a predominantly osteoblastic (sclerotic) nature is the outcome for the vast majority of patients with castration-resistant prostate cancer (CRPC). Pathologically, osteoblastic tumors are characterized ... -
The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease
(2012-11-30)The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is being also locally expressed and active in several organs ... -
The role of head size in total hip arthroplasty - Dislocation, wear and cup stability
(2021-02-24)Large heads are used in total hip arthroplasty, with the aim of reducing the risk of dislocation, but there are concerns related to polyethylene wear, corrosion and cup loosening. Paper I is an observational study that ... -
The role of physical activity for recovery after surgical procedures
(2021-02-18)The aim of this thesis was to determine the association between and effect of preoperative physical activity and postoperative recovery after surgery due to gallbladder disease or colorectal cancer. Paper I examined the ... -
The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases
(2021-11-23)Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further ... -
The Swedish Infant High-grade Reflux Trial - and a Focus group study of parents’ experiences
(2019-11-18)Background: Vesicoureteral reflux (VUR) is a pathological back-flow of urine from the bladder to the ureter and renal pelvis. VUR is associated with an increased risk of urinary tract infections (UTI) and renal damages. ... -
The Swedish Reflux Trial
(2010-08-30)Background Small children with dilated vesicoureteral reflux (VUR) run risk of recurrent uri¬nary tract infections (UTI) and to acquire renal damage. To protect them, antibiotic prophylaxis and surgery to eliminate VUR ... -
The use of fibrinogen in cardiac surgery patients-clinical and experimental studies
(2019-10-30)BACKGROUND Cardiac surgery with cardiopulmonary bypass impairs hemostasis due to hemodilution and consumption of platelets and coagulation factors, such as fibrinogen. The aim of this thesis was to study the role of ... -
Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment
(2014-04-11)Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for ... -
Therapy with 177Lu-octreotate - pharmacokinetics, dosimetry and kidney toxicity
(2014-05-12)177Lu-octreotate is used for treatment of patients with somatostatin receptor expressing neuroendocrine tumors in some clinics using a standard schedule. Renal and bone marrow toxicity are the main limiting factors. Results ... -
Three-dimensional guidance for Endovascular Aortic Repair
(2017-09-25)Image fusion (IF) of preoperative computed tomography (CT) with intraoperative cone-beam CT (CBCT) is a potentially powerful tool for guidance during endovascular aortic repair (EVAR). It may improve intraoperative anatomic ... -
Thymus dysfunction in the 22q11 deletion syndrome
(2023-04-12)Introduction: The 22q11.2 deletion syndrome (22q11DS) is associated with heterogeneous clinical findings, including T-cell immunodeficiency resulting from thymus hypoplasia. Newborn screening programs based on the ... -
Tight juntion in ovarian surface epithelium and epithelial ovarian tumors
(2007-03-22)Epithelial ovarian cancer originating from ovarian surface epithelium (OSE) is the most lethal type of gynecological cancer among women worldwide. The poor understanding of the cellular and molecular events associated with ... -
Tissue engineering for novel female infertillity treatments: studies on small and large animal models
(2021-02-25)Introduction: As with any transplantation (Tx) procedure, uterus Tx is associated with risky donor surgery and adverse side-effects from immunosuppression. With the aim to bypass these risks, this thesis investigated uterus ... -
Tissue remodelling proteases as prognostic factors in colon and rectal cancer
(2009-05-08)Background: Colorectal cancer is the third most common cancer in Sweden and the main treatment is surgery. The TNM classification is the principal staging tool, although insufficient in identifying all patients with poor ... -
Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2
(2014-03-07)The clinical success of bone implants of titanium (Ti) is largely ascribed to the biological performance and the physicochemical properties of the outermost titanium(IV)dioxide (TiO2) layer. Several advancements have been ...