Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 535-554 of 632
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Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma
(2022-11-22)Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage ... -
Studies of Sunscreens: Percutaneous Absorption of Benzophenone-3 and Photostability
(2006-10-20)Studies of Sunscreens: Percutaneous Absorption of Benzophenone-3 and Photostability Helena Gonzalez Department of Dermatology and Venereology Institute of Clinical Sciences The Sahlgrenska Academy at Göteborg ... -
Studies of tibial fractures using the Swedish Fracture Register
(2019-09-13)This thesis has two topics. First, the creation and application of the Swedish Fracture Register (SFR) is described. Second, a series of studies of tibial fractures based on data from the SFR follows. Until the start ... -
Studies on colonization and infection with Staphylococcus aureus and other microbes in skin disease
(2012-11-22)The skin is colonized with a wide range of microbes. Some offer vital protection from colonization and infection with pathogenic strains while others have the capacity to cause or exacerbate disease. The aim of this thesis ... -
Studies on glycosphingolipids in regenerative medicine
(2014-05-09)Regenerative medicine, including stem cell based therapies and xenotransplantation, is a new and developing field that aims to restore normal function in end stage cell/organ failure. However, in therapeutic settings ... -
Studies on nutrition, body composition and bone mineralization in healthy 8-yr-olds in an urban Swedish community
(2009-09-30)Background: The incidence of welfare diseases including overweight in childhood is increasing worldwide. The results from a study of healthy pre-school children showed that in a population with well educated parents 17% ... -
Studies on pathophysiological mechanisms in experimental models of acute renal failure
(2007-02-19)Acute renal failure (ARF) affects 5-20 % of critically ill patients and is an independent risk factor for death in this patient population. Reactive oxygen species, thrombin and endothelin-1 (ET-1) are increased in ARF, ... -
Sudden infant death syndrome-epidemiology and environmental factors. Prevention is still a challenge
(2016-01-13)Sudden infant death syndrome (SIDS) is still an important cause of death in infancy despite its declining incidence. The overall aim of this thesis was to study environmental factors influencing the risk of SIDS with the ... -
Superparamagnetic iron oxide for sentinel lymph node biopsy
(2024-04-18)Superparamagnetic iron oxide nanoparticles (SPIO), used as a tracer for sentinel lymph node (SLN) detection, offer several logistical benefits over the standard method using radioactive technetium-99m and blue dye. The ... -
Surgery and Ischemia in Uterus Transplantation. Studies in various experimental models.
(2007-09-10)The use of transplantation to enhance quality of life is a growing clinical field that also includes transplantation of reproductive organs. Transplantation of the uterus has been suggested as future method to treat uterus ... -
Surgery versus nonsurgical treatment of cervical radiculopathy. Randomized studies of anterior cervical decompression and fusion followed by physiotherapy versus structured physiotherapy alone
(2015-09-10)Background and aims: Cervical radiculopathy (CR) is a symptom complex comprising neck pain and radiating arm pain due to compression of one or more cervical nerve roots, caused by spondylotic narrowing of the intervertebral ... -
Surgical Management of Rib Fractures Following Trauma
(2019-04-08)Background: Surgical management of chest wall injuries has received increasing attention in recent years. The aim of this thesis was to study the mechanism of injury (MOI) in relation to chest wall injury patterns and ... -
Surgical methods in treating pancreatic tumours
(2018-05-03)Background: In patients with pancreatic cancer 15-20% are resectable at the time of diagnosis. Still another 8-20% are found to be unresectable at laparotomy. The optimal intraoperative strategy for this group is not known. ... -
Surgical restoration of grasp control in tetraplegia
(2013-02-27)Surgical Restoration of Grasp Control in Tetraplegia Carina Reinholdt Department of Orthopedics/Hand Surgery, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ABSTRACT Aim: ... -
Systems Biology Based Approaches to Identify Biomarkers in Seasonal Allergic Rhinitis
(2012-09-12)Glucocorticoids (GC) are the most effective anti-inflammatory treatment for seasonal allergic rhinitis (SAR). However, a few patients with SAR show poor response to GC treatment. Hence, there is a clinical need to find ... -
Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment
(2016-03-18)Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable ... -
Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
(2018-11-06)ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, ... -
Targeting Myc-driven tumours - BETing on ATR
(2016-03-17)Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell ... -
Testosterone, 17β-estradiol and pubertal growth
(2014-05-20)Background and aims: It is well established that the interaction of sex steroids with the growth hormone (GH)/ insulin-like growth factor 1 (IGF-1) axis is of major importance in children for normal pubertal growth. However, ... -
Thalidomide Embryopathy - Orthopaedic aspects. Degenerative changes and quality of life at age 45
(2016-11-18)In the late 1950s and early 1960s, a sudden peak was seen among children with different, severe malformations, caused by the intake of the drug thalidomide during pregnancy. Among other featured malformations, so-called ...