Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 471-490 of 634
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Psychosocial support needs after a breast cancer diagnosis
(2014-02-28) -
Public Health Aspects of Preterm Birth. Studies using Scandinavian population-based data
(2008-05-15)Background: Preterm birth is an unresolved serious global health problem. Research must be multi-disciplinary, with assessment of risk factors and causative agents at many levels of observation. Such an important level is ... -
Pulmonary atresia with intact ventricular septum epidemiology and outcome in children born in Sweden 1980-1999
(2008-04-22)Aims: To describe children born with pulmonary atresia with intact ventricular septum (PA-IVS) in Sweden between 1980 and 1999, the incidence and outcome of PA-IVS, to examine cardio-pulmonary outcomes in survivors and to ... -
Pulmonary ventilation and perfusion assessed by electrical impedance tomography - Experimental studies in pigs
(2009-08-28)Pulmonary ventilation and perfusion and ventilation/perfusion (V/Q) matching determine gas exchange in every lung unit in the healthy state and in the pathologically altered lung. Mismatch of V and Q lead to hypoxaemia and ... -
Pulse oximetry: Evaluation of a potential tool for early detection of critical congenital heart disease
(2009-03-31)Background: About one third of newborns with life-threatening congenital heart disease leave newborn nurseries without the problem being recognized, and risk death or serious damage from circulatory collapse. The main aim ... -
Pulse-Synchronous Intramuscular Pressure Oscillations
(2016-01-12)Background Intramuscular pressure (IMP) is measured in studies of tissue nutrition and in the diagnosis of compartment syndromes. Patients with compartment syndromes have an elevated IMP due to increased volume in a ... -
Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Quality of life and morbidity in patients with rectal cancer
(2016-10-24)Aim: The aim of this thesis was to investigate patient-reported and clinical outcome in patients with rectal cancer with specific focus on treatment-associated morbidity and quality of life. Method: Three clinical studies ... -
Quality of life and psychological reactions in women on first line chemotherapy for metastatic breast cancer - Correlations to tumour response and predictive factors.
(2011-03-25)Background: Health-related quality of life (HRQoL) is an important endpoint in clinical trials and as an aspect that must be considered in the treatment of patients with metastatic breast cancer. Treatment efficacy and ... -
Radiation-induced dysphagia in head and neck cancer - risk structures and methodological aspects
(2019-08-19)Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating ... -
Radiobiological effects of alpha-particles from Astatine-211: From DNA damage to cell death
(2011-05-26)ABSTRACT In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an -particle emitting radionuclide, promising ... -
Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
(2015-04-08)Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. 211At ... -
Radiological evaluation of esophageal function in dysphagia with special emphasis on achalasia
(2008-10-03)In idiopathic achalasia, degeneration of the inhibitory innervation of the esophageal smooth muscle results in absence of primary peristalsis and in incomplete relaxation of the lower esophageal sphincter (LES). All ... -
Radiotherapy and voice rehabilitation in laryngeal cancer: Effects on quality of life and voice function
(2015-02-27)The overall aim of the thesis was to describe the effects of radiotherapy following laryngeal cancer on health-related quality of life (HRQL) and voice function as well as to assess the efficiency of voice rehabilitation. ... -
Radiotherapy-induced late effects among female pelvic cancer survivors - sexual health, wellbeing, and impact of nurse-led interventions
(2022-09-01)This thesis addresses unmet needs concerning sexual health issues and low wellbeing in female cancer survivors treated with pelvic radiotherapy. The aim was to improve knowledge about sexual health, wellbeing and vaginal ... -
Recovery after surgically treated distal radius fracture - Aspects of evaluation and rehabilitation
(2022-11-14)BACKGROUND A distal radius fracture (DRF) is a common injury, occurring in both genders and during the entire life span, although it is most common in elderly women. An uncomplicated fracture is treated with a cast, but ... -
Recruitment of small size lungs - experimental studies
(2012-05-15)Background: Patients - both children and adults - undergoing anesthesia and mechanical ventilation rapidly develop atelectasis. Even more severe problems occur in patients with acute lung injury/acute respiratory distress ... -
Rectal Cancer and Quality of Life. Aspects on Communication and Patient Education
(2021-03-16)Background This thesis reports the results of three studies based on a pro-spective cohort study of an unselected population of patients with rectal cancer, and one study based on an exploratory study of a new patient ... -
Recurrent unexplained first-trimester miscarriage. Effects of acetylcalicylic acid, platelet aggregation and thyroid disease
(2019-10-18)Recurrent unexplained first-trimester miscarriage. Effects of acetylsalicylic acid, platelet aggregation and thyroid disease. Lennart Blomqvist, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, ... -
Regenerative effects of mesenchymal stem cell-derived exosomes
(2019-02-06)Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has ...