Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 446-465 of 628
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Predicting mortality by comorbidity for patients with hip arthroplasty: Prospective observational register studies of a nationwide Swedish cohort
(2020-08-19)INTRODUCTION: Patients with total hip arthroplasty (THA) due to osteoarthritis (OA) are usually healthy, some with a remaining lifetime of several decades after surgery. Patients with hip arthroplasty due to a femoral ... -
Prediction of embryo viability by morphology and metabolomic profiling
(2013-01-25)Abstract The ultimate challenge for all in vitro fertilisation (IVF) clinics is to develop the ability to select for transfer the best single embryo first, from the patient’s cohort of embryos, thereby maximising the ... -
Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury
(2015-03-30)Background: Severe traumatic brain injury (sTBI) is the most common cause of mortality in young adults. sTBI induces variable brain damage, invisible in Computer Tomographic scans early post-trauma. Further, neurology ... -
Predictors of Complications after Anterior Cruciate Ligament Injury
(2015-04-10)BACKGROUND: An anterior cruciate ligament (ACL) tear is a serious knee injury that frequently affects young individuals active in soccer, alpine skiing, handball and basketball. Regardless of treatment, an ACL injury is ... -
Pretargeting agents and At-211-labeled effector molecules: Synthesis and preclinical evaluation for pretargeted alpha-radioimmunotherapy.
(2012-05-15)Targeted therapies are treatment regimens in which tumor specific substances incorporating some sort of cell-killing effect are administered to patients. For cancer therapy they have emerged as a means of preventing ... -
Prevention and treatment of acute kidney injury after cardiac surgery
(2010-06-01)Acute kidney injury (AKI) occurs frequently after cardiac surgery and is independently associated with increased mortality. The main cause of AKI in these patients is renal ischemia. However, data on the renal oxygenation, ... -
Primordial radionuclides in pit lakes in Sweden
(2020-05-07)In Sweden, there are many pit lakes, originating from limestone quarries and metal mines, with unknown status in regard to the activity concentration of radionuclides. Such knowledge is generally available only for pit ... -
Principles of scaffold generation for bioengineering of the ovary and uterus: a study focusing on decellularization
(2021-05-27)Introduction: Cancer therapy often result in fertility problems due to inflicted injury to the reproductive organs. Since most women survive cancer, fertility preservation has become an important consideration during cancer ... -
Prognostic and predictive factors in colorectal cancer
(2009-02-06)Aim: The aim of the thesis was to study prognostic and predictive factors in patients treated for colorectal cancer (CRC). Method: In paper I, a retrospective comparison was made between the patients treated in 1999 ... -
Prognostic factors and tumor treatments in hepatocellular cancer
(2019-03-04)Background: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Prognosis is related to tumor burden, liver function, and performance status as well as treatment factors. ... -
Prognostic impact of coronary microvascular funtion in patients with ischemic heart disease.
(2018-03-09)Background: Ischemic heart disease is the leading cause of death globally. Despite recent advances in interventional and medical therapies, survivors of myocardial infarction are at high risk of recurrent cardiovascular ... -
Promoting the Clinical Relevance of 3D Bioprinting
(2022-02-03)This thesis focuses on the development of methodologies enabling the reconstruction of autologous, functional, and long-term-stable cartilage-like tissue using 3D bioprinting technology and animal experiments. The stability, ... -
Prostaglandins and angiogenesis in experimental cancer
(2010-04-08)Background and aim. Genes, proteins and pathways have been identified and suggested as potential targets in tumor angiogenesis, but current anti-angiogenic therapies have provided only modest benefits in survival of cancer ... -
Prostanoids and colorectal cancer
(2010-10-22)Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. ... -
Prostate Cancer and Its Influence on Men´s Daily Lives
(2009-09-30)Prostate cancer has been a disease of older men but age at diagnosis is falling in Sweden. Fatigue has been regarded as a common symptom of cancer and may compromise quality of life in prostate cancer patients. The overall ... -
Prostate Cancer Screening - Aspects of Overdiagnosis
(2014-11-28)The overall aim of this thesis is to explore aspects of overdiagnosis, i.e. the diagnosis of a tumor that in the absence of screening would never have been diagnosed, in prostate cancer (PC) screening. The four papers in ... -
Prostate cancer screening with PSA - A study of potential negative consequences
(2010-11-19)Aims: The Göteborg randomized population-based prostate cancer screening trial is a prospective study evaluating the efficacy of prostate-specific antigen (PSA)-based screening and its effect on prostate cancer mortality. ... -
Prostate Cancer Screening: Outcomes and Risk Prediction
(2018-12-12)Prostate Cancer Screening: Outcomes and Risk Prediction Maria Frånlund, MD Department of Urology, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sweden ABSTRACT The Göteborg Randomized ... -
Prostate Diseases and the Metabolic Syndrome
(2015-04-23)ABSTRACT The overall aim of this thesis was to explore the association between the components of the metabolic syndrome (MetS), including vitamin D, and lower urinary tract symptoms (LUTS). The focus was on the relationship ... -
The proteasome as a target for cancer therapy
(2023-05-23)The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The ...