Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 333-352 of 628
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Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells
(2018-02-22)Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to ... -
Metopic synostosis - surgical results and perinatal aspects
(2022-04-27)Metopic synostosis (MS) is the second most common type of craniosynostosis (CS). This thesis aimed to evaluate surgical results in children operated for MS, their perinatal outcomes and potential etiological risk ... -
Microcirculation in tissue repair - from microsurgery to 3D bioprinting
(2021-03-03)Microsurgical reconstruction is challenged by two main shortcomings: Perfusion Related Complication (PRC) and donor site morbidity. In the first 3 studies of this thesis, we aimed to provide solutions to PRC-problems, ... -
Microdosimetry of radiohalogens in thyroid models
(2014-02-10)The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with ... -
Midkine in Advanced Prostate Cancer - Biological Impact and Biomarker Potential
(2017-12-15)Prostate cancer (PC) is generally an androgen-driven disease, why androgen deprivation therapy (ADT) is the cornerstone for treatment of advanced and metastatic hormone-naïve PC (HNPC). ADT generally offers a good initial ... -
Migration of Natural Killer Cells. Matrix interaction, locomotion and regulation of matrix metalloproteinases (MMPs) by IL-2 and chemokines
(2009-08-28)Activated natural killer (NK) cells are effective anti-tumour cells. In order to reach target cells in a tumour mass they need to migrate in the extravascular space. The process of tumour localisation begins when the NK ... -
Mild primary hyperparathyroidism - Long-term effects of parathyroidectomy versus observation - with emphasis on skeletal outcomes
(2022-03-29)Background: The majority of patients with primary hyperparathyroidism (PHPT) in developed countries today present with no obvious symptoms, i.e. the mild form of the disease. As the only curative treatment is parathyroidectomy ... -
Modulation of Inflammatory Response in Surgical Trauma
(2012-09-12)Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. The thesis aims to describe the body's inflammatory ... -
Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
(2014-05-09)Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate ... -
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ... -
Molecular characterization of type I endometrial carcinomas
(2009-02-10)Endometrial carcinoma is the most common malignancy in the female reproductive tract. In Sweden over 1300 women are diagnosed every year, and although the prognosis is favourable in the majority of cases, about 160 ... -
Monitoring alveolar recruitment in the critically ill - Patient studies using electric impedance tomography and volume-dependent compliance
(2010-11-19)Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with a high mortality rate and poor long term outcome in terms of quality of life, for those who survive. Similarly, patients ... -
Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods
(2022-05-23)Background: Cystic Fibrosis (CF) is an inherited progressive disease that causes severe damage to the airways and other organs of the body. Many methods are available to track CF lung disease but longitudinal data are ... -
Morbidity and mortality following standardised perioperative management of patients operated with acute abdominal surgery in a high-risk emergency setting
(2023-11-06)Patients suffering from acute pathology in the abdomen is common throughout the world and surgical intervention can often be necessary. Those who are most seriously ill need an acute management with major abdominal surgery, ... -
Motion Analysis and Postural Stability of Transtibial Prosthesis Users
(2011-12-20)The AIMS of the thesis were to critically evaluate motion analysis methods used during investigations of transtibial prosthesis users, and to propose improvements to these methods. Additionally, the aim was to evaluate ... -
Multimodal and multiscale characterization of bone and bone interfaces in health and disease
(2023-05-16)Seeing is believing. Our understanding of phenomena often involves their direct observation. However, bone architecture is challenging to visualize given its multi-level hierarchical organization. In this thesis, bone and ... -
Multiparametric MRI for evaluation of tumour treatment response
(2016-11-18)Clinical assessment of tumour response to treatment largely relies on estimates of tumour size by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed tomography (CT) images, weeks or ... -
MUSCLE STRENGTH, GROSS MOTOR FUNCTION AND GAIT PATTERN IN CHILDREN WITH CEREBRAL PALSY
(2009-01-12)Aim The main purpose was to explore the relationship between muscle strength and walking ability in children with bilateral spastic cerebral palsy (CP), and to analyse whether muscle strength training can improve walking ... -
MUSCLE TONE IMBALANCE IN HUMAN UPPER EXTREMITY An experimental study of muscle adaptation to altered tension
(2008-11-28)Aim: The aim of this thesis was to improve outcome after tendon transfer and rotator cuff surgery by investigating the impact on response to passive mechanical testing and change in structural characteristics associated ... -
Narcolepsy in children: Relationship to the H1N1 influenza vaccination, association with psychiatric and cognitive impairments and consequences in daily life
(2016-09-06)Background/aims: Narcolepsy is a lifelong sleep disorder with an onset most frequently in the second decade of life. The cardinal symptoms are excessive daytime sleepiness, cataplexy, hypnagogic and hypnopompic hallucinations ...