Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 310-329 of 632
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Longitudinal outcome following total hip replacement. Time trends, sequence of events and study of factors influencing implant survival and mortality
(2018-02-23)Osteoarthritis of the hip is a common, debilitating and symptomatic joint disease. The disabling symptoms can be successfully treated with a total hip replacement (THR). It is known that the majority of patients do well ... -
Longitudinal study of infants with high-grade vesicoureteral reflux
(2009-09-09)Background: Infants with congenital high-grade vesicoureteral reflux (VUR) have been regarded as a special group amongst children with reflux, with their own characteristics concerning renal damage, gender, resolution rate ... -
Lower Urinary Tract symptoms in women - aspects on epidemiology and treatment
(2009-04-17)Lower urinary tract symptoms in women – aspects on epidemiology and treatment Lower urinary tract symptoms (LUTS) are common conditions that compromise a person’s quality of life and result in increased health care costs ... -
Lumbar Disc Herniation Surgery - Novel Approaches, Timing and Outcomes
(2021-11-16)Lumbar Disc Herniation Surgery – Novel Approaches, Timing and Outcomes JOEL BECK Department of Orthopaedics, Institute of clinical sciences, Sahlgrenska academy, University of Gothenburg, Sweden, 2021 ABSTRACT BACKGROUND ... -
Lung and chest wall properties during mechanical ventilation
(2018-11-16)Background: Mechanical ventilation causes injury to the lungs due to high pressures and high volumes. Pressure affecting the lungs, the transpulmonary pressure, needs to be monitored to minimise harmful side effects but ... -
Lung Emphysema & Cardiac Function
(2008-03-07)Patients with severe lung emphysema have poor quality of life because of impaired lung function and reduced exercise tolerance. Concomitant heart disease in severe emphysema is well recognised. The prevailing view is that ... -
Lutetium-177-octreotate treatment of small intestine neu-roendocrine tumors - Radiation biology as basis for optimization
(2016-12-19)Patients with neuroendocrine tumors (NETs) often have metastatic spread at the time of diagnosis. NETs frequently express somatostatin receptors (SSTR) that can be targeted by radiolabeled somatostatin analogs (e.g. ... -
Magnetic Resonance Imaging as a Screening Tool for Prostate Cancer
(2021-04-20)The overall aim of this thesis was to explore the role of Magnetic resonance imaging (MRI) of the prostate as an adjunct to the prostate-specific antigen (PSA)-test in screening for prostate cancer (PCa), focusing on the ... -
Maintaining quality of life after prostate cancer diagnosis
(2011-09-30)Knowledge of real-life factors that are associated with men’s self-assessed quality of life after prostate-cancer diagnosis could improve the support from health-care professionals in maintaining the men’s quality of life. ... -
Management of late term pregnancy
(2021-02-17)Background: The optimal time point to intervene and induce labour in women with a low-risk pregnancy, in order to decrease perinatal adverse outcome, is up for debate. Some advocate for induction of labour (IOL) at 41 ... -
Markers and mechanisms of abnormal neurovascular development in the preterm infant
(2023-01-18)Background: The extremely preterm infant is at risk of lifelong neurodevelopmental impairments due to brain injuries or abnormal neurovascular development. Mechanisms are largely unknown and biomarkers for adverse outcomes ... -
Maternal and placental inflammatory biomarkers in spontaneous preterm delivery - Predictive ability, stability and neonatal associations
(2017-03-28)Preterm delivery (PTD), spontaneous or iatrogenic, causes short- and long-term morbidity and underlies almost 75% of neonatal deaths. The prevalence in the Nordic countries is about 6% but it differs among countries. In ... -
Mean systemic filling pressure - from Guyton to the ICU, and back again
(2019-02-01)Introduction: Mean systemic filling pressure (MSFP) is the equilibrated vascular pressure at zero flow. Venous return (VR) driving pressure (VRdP) is the difference between MSFP and right atrial pressure (RAP). In clinical ... -
Measurement of outcome in lumbar spine surgery
(2020-04-02)BACKGROUND. The purpose of elective lumbar spine surgery is mainly to reduce pain and to improve physical function and quality of life. The quality and results of the interventions are monitored in the Swedish spine register, ... -
Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD
(2015-09-16)Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for ... -
Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer
(2018-03-02)Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or ... -
Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
(2009-11-26)Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development ... -
Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ... -
Melanoma surgery in the era of modern immunotherapy
(2024-01-30)Recent advances in immuno-oncology have led to a paradigm shift in the treatment of advanced cutaneous melanoma. The aim of this thesis is to investigate the role of surgery in the management of melanoma in this modern era ... -
Mental adjustment and Health-related: Quality of Life In laryngeal cancer patients Quantitative and Qualitative approaches
(2010-08-30)The overall aim of this thesis was to investigate mental adjustment and HRQL in patients treated for laryngeal cancer. Specific aims were to evaluate if either VAS or Likert response options was more suitable when assessing ...