Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 106-125 of 634
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Characterization of genetic alterations in ovarian cancer associated with chemotherapy response
(2009-05-13)Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy ... -
Characterizing and modulating the effects of ionizing radiation to the juvenile hippocampus
(2014-05-09)Survival rates after childhood cancer treatment have improved, leading to a growing population of survivors. Radiotherapy is an important tool for curing cancer in the brain. Unfortunately, radiotherapy is associated with ... -
Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers
(2023-08-21)Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing ... -
Chest Tomosynthesis for Detection and Surveillance of Pulmonary Pathology. Studies on Cystic Fibrosis and Solid Pulmonary Nodules
(2019-06-17)Introduction: Digital tomosynthesis (DTS) is a relatively new imaging modality in thoracic imaging. The technique is based on the equipment of conventional radiography, upgraded with a moving tube that enables separation ... -
Childhood asthma. Epidemiology, prevalence and risk factors
(2023-05-09)Background and aim: Asthma is one of the most common chronic diseases among children often resulting in medical treatment, morbidity and reduced quality of life. It is therefore important to study factors associated with ... -
Children and adolescents with Type 1 Diabetes Mellitus: family dynamics and health-related quality of life after diabetes onset
(2015-05-21)ABSTRACT Aim: The main aim of this thesis was to explore different aspects of family dynamics and health- related quality of life (HRQOL) after the onset of T1DM in children and adolescents. A second aim was to ... -
Children injured in traffic in a medical and psychosocial perspective : causes and consequences
(2014-04-25)Aim: To examine the causes and consequences of road traffic injuries in children from a physical and psychosocial perspective, and to identify unfavourable circumstances and children who are at risk of injury and ... -
Chronic Achilles tendon rupture - surgical reconstruction and post-operative outcomes
(2023-03-28)When the treatment of Achilles tendon ruptures is delayed by more than 4 weeks, the rupture is classified as chronic. This thesis aims to examine the postoperative outcome of chronic Achilles tendon ruptures treated ... -
Chronic limb-threatening ischaemia - Prognosis after intervention
(2019-04-26)Introduction: Lower-extremity arterial disease (LEAD) is a major health problem worldwide. Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of LEAD. Open or endovascular recanalization is recommended ... -
Chronic Rhinosinusitis with Nasal Polyps - Symptoms, Heredity and Genetics
(2019-04-26)ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by long-term inflammation of the paranasal sinuses combined with bilateral glassy protuberances from the middle meatus of the nasal cavity. This ... -
Clinical and arthroscopic assessment of wrist ligament injuries and instability
(2016-04-11)Wrist ligament injuries are common after trauma, especially when concomitant dislocated radius fractures are present. The diagnostics of scapholunate (SL), lunotriquetral (LT) and triangular fibrocartilage complex ... -
Clinical and experimental studies on oxidized fragrance terpenes as contact allergens
(2009-03-02)The work presented in this thesis aims to improve the possibilities for diagnosing contact allergy to oxidized limonene and linalool and to, in patients, study contact allergy from structurally closely related hydroperoxides ... -
Clinical and genetical aspects of Celiac Disease
(2008)Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e ... -
Clinical and molecular studies of liposarcoma
(2007-05-21)Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse ... -
Clinical and radiographic evaluation after ACL reconstruction with the emphasis on surgical technique and time of reconstruction
(2018-05-07)The overall purpose of this thesis was to assess the short-, mid- and long-term clinical and radiographic results after anterior cruciate ligament (ACL) reconstruction, in relation to different surgical techniques, such ... -
Clinical aspects of olfaction
(2008-09-10)The most important aims of this thesis were: (1) to investigate the prevalence of olfactory dysfunction in an adult Swedish population and to relate dysfunction to factors of possible impact on olfaction, (2) to present ... -
Clinical implementation of novel diagnostic biomarkers for epithelial ovarian cancer - Can we improve diagnosis?
(2020-04-01)Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The 5-year survival is about 30%, a consequence of failure to establish early diagnosis due to unspecific symptoms. The biomarker serum ... -
Clinical Outcome and Prognostic Factors in Borderline Ovarian Tumors and Invasive Ovarian Carcinomas in Western Sweden
(2008-11-24)Ovarian cancer, the most lethal of gynecological malignancies in Sweden, is first diagnosed in advanced stages in two thirds of the cases. Although the incidence is decreasing, mortality remains high. Clinical guidelines ... -
Clinical utility and evaluation of radiology in diagnosing sacroiliitis
(2008-10-27)Background: Radiographic confirmation of diagnosis is important in all diagnostic and classification criteria for spondyloarthropathy. The aim was to evaluate computed tomography (CT) and to compare it to radiography. Methods: ... -
Clinical, biochemical and morphological aspects of cervical ripening in the first trimester
(2009-09-18)Background: The uterine cervix has the ability to be transformed from being a rigid organ in non-pregnant women to become a loose structure that dilates and allows passage of the foetus at parturition. This process, cervical ...