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Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency


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Title: Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency
Authors: Barbosa, Edna de Jesus Litenski
E-mail: edna.barbosa@medic.gu.se
Issue Date: 10-Oct-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Internal Medicine
Parts of work: I. Barbosa EJL, Koranyi J, Filipsson H, Bengtsson B-Å, Boguszewski C, Johannsson G. Models to predict changes in serum IGF-I and body composition in response to GH replacement therapy in GH-deficient adults. European Journal of Endocrinology (2010) 162: 869-878.
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II. Barbosa EJL, Palming J, Glad CAM, Filipsson H, Koranyi J, Bengtsson B-Å, Carlsson LMS, Boguszewski CL, Johannsson G. Influence of the exon3-deleted/full-length growth hormone (GH) receptor polymorphism on the response to GH replacement therapy in adults with severe GH deficiency. J Clin Endocrinol Metab (2009) 94: 639-641.
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III. Barbosa EJL, Glad CAM, Nilsson AG, Nyström HF, Götherström G, Svensson P-A, Vinotti I, Bengtsson B-A, Nilsson S, Boguszewski CL, Johannsson G. Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of growth hormone deficient (GHD) adults before and after GH replacement therapy. Eur J Endocrinol (2012) 167: 353-362.
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IV. Barbosa EJL, Glad CAM, Nilsson AG, Bosaeus N, Nyström HF, , Svensson P-A, Bengtsson B-A, Nilsson S, Bosaeus I, Boguszewski CL, Johannsson G. Genotypes associated with growth hormone (GH) signaling pathway and renal function contribute to differences in the extracellular water volume of GH deficient adults. Unpublished manuscript.
Date of Defence: 2012-10-12
Disputation: Fredagen den 12 oktober 2012, kl. 09.00, i Arvid Carlssons hörsal, Göteborgs Universitet
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: growth hormone deficiency
hypopituitarism
growth hormone replacement therapy
prediction models
candidate gene approach
polymorphisms
body composition
growth hormone receptor
lipid metabolism
extracellular water
pharmacogenomics
Abstract: The overall aim of this thesis was to study clinical and genetic factors that influence response to growth hormone replacement therapy (GHRT) in GH deficient (GHD) adults. The patients were part of a cohort of adults with hypopituitarism and severe GHD who were studied before and after 12 months of GHRT. The dose regimen was individualized in order to attain normal IGF-I levels. Logistic regression (LR) analysis was used to identify good and poor responders to GHRT. The candidate gene approach w... more
ISBN: 978-91-628-8546-5
URI: http://hdl.handle.net/2077/29711
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

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