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Mutation screening of melatonin-related genes in patients with autism spectrum disorders


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Title: Mutation screening of melatonin-related genes in patients with autism spectrum disorders
Authors: Jonsson, Lina
Ljunggren, Elin
Bremer, Anna
Pedersen, Christin
Landén, Mikael
Thuresson, Kent
Giacobini, MaiBritt
Melke, Jonas
Issue Date: 8-Apr-2010
Publication type: article, peer reviewed scientific
Organization: Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg University, Sweden
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Neuropsychiatric unit of Mölndals hospital at the University of Gothenburg, Sweden
Citation: BMC Medical Genomics. 2010 Apr 08;3(1):10
Abstract: Abstract Background One consistent finding in autism spectrum disorders (ASD) is a decreased level of the pineal gland hormone melatonin and it has recently been demonstrated that this decrease to a large extent is due to low activity of the acetylserotonin O-methyltransferase (ASMT), the last enzyme in the melatonin synthesis pathway. Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, ... more
ISBN: http://dx.doi.org/10.1186/1755-8794-3-10
ISSN: 1755-8794
Description: © 2010 Jonsson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/29643
Appears in Collections:Articles / Institute of Neuroscience and Physiology

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