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The cerebrospinal fluid proteome in HIV infection: change associated with disease severity

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Title: The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
Authors: Angel, Thomas E
Jacobs, Jon M
Spudich, Serena S
Gritsenko, Marina A
Fuchs, Dietmar
Liegler, Teri
Zetterberg, Henrik
Camp II, David G
Price, Richard W
Smith, Richard D
Issue Date: 20-Mar-2012
Publication type: article, peer reviewed scientific
Organization: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Citation: Clinical Proteomics. 2012 Mar 20;9(1):3
Abstract: Abstract Background Central nervous system (CNS) infection is a nearly universal feature of untreated systemic HIV infection with a clinical spectrum that ranges from chronic asymptomatic infection to severe cognitive and motor dysfunction. Analysis of cerebrospinal fluid (CSF) has played an important part in defining the character of this evolving infection and response to treatment. To further characterize CNS HIV infection and its effects, we applied advanced high-throughput proteomic methods... more
ISSN: 1559-0275
Description: © 2012 Angel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Articles / Institute of Neuroscience and Physiology



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