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Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways


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Title: Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways
Authors: Cui, Zhi-Hua
Rådinger, Madeleine
Sjöstrand, Margareta
Lötvall, Jan
Issue Date: 22-Mar-2012
Publication type: article, peer reviewed scientific
Organization: Krefting Research Centre, Department of Internal Medicine and Clinical nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Citation: Clinical and Translational Allergy. 2012 Mar 22;2(1):7
Abstract: Abstract Background Allergen induced early phase airway response and airway plasma exudation are predominantly mediated by inflammatory mast cell mediators including histamine, cysteinyl leukotrienes (cysLTs) and thromboxane A2 (TXA2). The aim of the present study was to evaluate whether repeated allergen exposure affects early phase airway response to allergen challenge. Methods A trimellitic anhydride (TMA) sensitized guinea pig model was used to investigate the effects of low dose repeated al... more
ISBN: http://dx.doi.org/10.1186/2045-7022-2-7
ISSN: 2045-7022
Description: © 2012 Cui et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/29229
Appears in Collections:Articles / Institute of Medicine

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