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Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: A TransATAC study


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Title: Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: A TransATAC study
Authors: Lundgren, Katja
Brown, Matthew
Pineda, Silvia
Cuzick, Jack
Salter, Janine
Zabaglo, Lila
Howell, Anthony
Dowsett, Mitch
Landberg, Göran
-, On behalf of the TransATAC investigators
Issue Date: 4-Apr-2012
Publication type: article, peer reviewed scientific
Organization: Sahlgrenska Cancer Center, University of Gothenburg, 405 30 Göteborg, Sweden
Citation: Breast Cancer Research. 2012 Apr 04;14(2):R57
Abstract: Abstract Introduction Gene amplification of CCND1 is observed in a subgroup of breast cancers with poor prognosis, whereas overexpression of the protein cyclin D1 has been linked to both worse and better clinical outcome. CCND1 amplification and protein overexpression have also been associated with resistance to treatment with tamoxifen or even to a potentially detrimental effect of tamoxifen. Methods To clarify these challenging and partly contrasting treatment predictive and prognostic links f... more
ISBN: http://dx.doi.org/10.1186/bcr3161
ISSN: 1465-5411
Description: © 2012 Lundgren et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/29197
Appears in Collections:Articles / Institute of Biomedicine

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