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Adaptation and Protein Quality Control Under Metalloid Stress
(2015-04-22)
Toxic metals and metalloids are emerging as major environmental pollutants, having ecological consequences as well as being linked to a broad range of degenerative conditions in animals, plants and humans. While the toxicity ...
The Structural Modularity and Inherent Dynamics of the DegP Protease together with its Intertwined Role in the Bacterial Periplasm
(2021-12-09)
The protein quality control machinery is a delicate and integrated network of molecular tools working together to fold or remove unwanted proteins from the cell. A distinct set of “gatekeepers” are involved in this process ...
Functional details of human HtrA2 protease studied by NMR spectroscopy
(2022-11-24)
Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function ...