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Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
(2021-01-27)
Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ...
The molecular chaperone CCT: Functions beyond folding
(2021-10-07)
The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal ...
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional
serine/threonine kinase and endoribonuclease that is the major mediator of
the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
The association ...