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Lipidic Cubic Phase Microcrystallization and its Application in Serial Crystallography
(2020-10-23)
Every living organism contain a cell membrane which is an important cell structure with a vast variety of different functions such as cell signaling, transportation and energy production. One of the most important functions ...
Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors
(2021-08-26)
Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong ...
Salting-out of Colloidal Latex Particles Grafted with Poly(ethylene glycol)
(2020-01-15)
Colloidal particles dispersed in a medium are important both in nature and in industry. The stability of colloidal particles is determined by the interactions between them and can be improved by steric stabilization. There ...
Reverse structural biology: Cellular processes uncovered by electron microscopy
(2021-03-25)
This thesis contains two projects, both using electron microscopy as the primary technique. In the first project, nuclear envelope budding (NEB) is investigated as an alternate method of transport across the nuclear ...
Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
(2021-01-27)
Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ...
LOOK AROUND, WHAT CAN YOU DISCOVER? The science center - a critical space for science student teachers’ development
(2021-04-21)
This thesis aims to examine the opportunities and constraints on student teachers’ learning of science
and teaching science when they work in small groups; planning, implementing, and reflecting upon
teaching at the ...
Electromagnetic Field Induced Out-of-Equilibrium Structural Dynamics in Protein Crystals: From Picoseconds to Milliseconds
(2022-02-04)
Light-induced interactions in biomolecules are strongly varying over different model systems. Most amino acids and proteins absorb ultraviolet light, but only a few with specialised chromophores or fluorophores, are able ...
Quantum dynamical effects in complex chemical systems
(2020-05-12)
When using mathematical models to computationally investigate a chemical system it is important that the methods used are accurate enough to account for the relevant properties of the system and at the same time simple ...
The molecular chaperone CCT: Functions beyond folding
(2021-10-07)
The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal ...
Investigation of Exocytosis for a New Paradigm of Plasticity in Biological Systems Using Electrochemistry and Mass Spectrometry Imaging
(2021-05-05)
Cellular communication is a vital process and serves as the basis for complex brain functions in multicellular organisms. The majority of cellular communication is achieved via the release of specific signaling molecules, ...