Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Issue Date
Now showing items 21-40 of 203
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Breaking the symmetry: creation and transfer of optical activity via total spontaneous resolution and stereoselective reactions
(2013-03-28)The generation of optical activity from achiral or racemic precursors – absolute asymmetric synthesis – is discussed in relation to the origin of biomolecular homochirality but is also often (incorrectly) regarded as ... -
Structural analyses of immune cell receptor signalling and activation
(2013-04-17)Structural biology is a scientific field where the aim is to observe macromolecules on a atomic level to understand their functions. Often these macromolecules are proteins that make, almost, everything happen within the ... -
Advances in Membrane Protein Structural Biology: Lipidic Sponge Phase Crystallization, Time-Resolved Laue Diffraction and Serial Femtosecond Crystallography
(2013-05-08)Membrane proteins carry out many essential tasks in cells such as signaling and transport, or function as electron carriers in photosynthesis and cellular respiration. The aim of this thesis has been to develop new and ... -
Iron catalyzed C-C coupling reactions - mechanistic investigations
(2013-05-14)The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated ... -
The Mechanisms of Exocytosis Studied in Cells and Models with Amperometry
(2013-05-15)Exocytosis is the universal basis for neuronal communication, allowing the controlled release of neurotransmitter molecules from the presynaptic cell. Exocytosis has been widely studied in many systems. However, the details ... -
Low biocide emission antifouling based on a novel route of barnacle intoxication
(2013-05-17)Marine biofouling can be defined as the colonization of man-made surfaces in seawater by microscopic and macroscopic organisms. This phenomenon can result in great loss of function and effectiveness both for cruising ships ... -
Hydrous iridium oxide for in-situ pH sensing: electrodeposition, properties and applications.
(2013-05-20)For heterogeneous processes, such as electrochemical reactions taking place at an elec- trode, the chemical conditions at the reaction interface can differ significantly from the bulk. Consumption of reactants leads to ... -
Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
(2013-09-05)It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and ... -
Allergenic Oxidation Products from Fragrance Terpenes. Chemical Analysis and Determination of Sensitizing Potency
(2013-09-05)The ubiquitous presence of fragrance compounds in consumer products has resulted in a high frequency of contact allergy to fragrances in the population. For prevention purposes and according to EU regulations, cosmetics ... -
Character and Function of Anammox Bacteria under Environmental Stress
(2013-09-16)During the last few decades observations of novel processes involved in nitrogen transformations have fundamentally challenged the view of pathways and controlling mechanisms during local and global nitrogen cycling. ... -
Development and use of an optical pCO2 sensor in marine studies
(2013-10-04)Partial pressure of CO2 (pCO2) is one of the most important parameters, which are measured in the global ocean in conjunction with ocean acidification studies. It is also a parameter of great interest to aquaculture and ... -
On Biogenic Halocarbons in Antarctic Waters
(2013-10-17)Little is known regarding the distribution of naturally produced volatile halogenated organic compounds, halocarbons, in Antarctic waters and the contribution of these waters to the global atmospheric load of halogens. In ... -
Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships
(2013-10-31)Chemicals in our environment with which we have repeated skin contact can cause skin sensitisation (contact allergy). To trigger an immune response a compound (hapten) must be able to penetrate the skin, where it needs to ... -
Production and Characterisation of Aquaporins and Proton-Translocating Transhydrogenase
(2013-11-15)Dissertation Abstract Water transport in eukaryotic cells is a highly regulated and fine-tuned process. Water channel protein known as aquaporins (AQPs), constitute the main cellular water transport system, preserving ... -
New single particle methods for detection and characterization of nanoparticles in environmental samples
(2013-11-28)Nanoparticles (NP) are being used in rapidly increasing quantities which has resulted in concerns about possible harmful effects for health and environment. NP are already undergoing similar risk assessment programs as ... -
On the exposure assessment of engineered nanoparticles in aquatic environments
(2013-12-10)The socio-economic benefits anticipated with the use and production of nanomaterial and nanoparticles in consumer products are linked to the fulfillment of the requirement for sustainability during the whole material life ... -
Electrocatalytic properties of Ni hydroxides with Zn or Co in the Ni matrix
(2014-01-17)The majority of the work in this thesis has been made with the improvement of the systems for electrochemical co-generation of chemicals and electricity in mind. This is an appealing but challenging way of producing chemicals ... -
Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
(2014-03-07)Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of ... -
Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery
(2014-03-18)The increasing incidences of cancer and related deaths call for the development of new and improved treatment modalities. Photodynamic therapy (PDT) today is an alternative to conventional treatments, but has limitations. ... -
Quantum Force in Wigner Space
(2014-04-08)In this thesis, I will present effective methods to study quantum dynamics using trajec- tories. Our methods are based on a method named the Classical Wigner model which starts with a quantum initial condition and generates ...