Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 135-154 of 191
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Quantitative chemical imaging to study content release from single nanovesicles
(2023-12-05)Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, ... -
Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics
(2023-04-28)Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is ... -
Quantum dynamical effects in complex chemical systems
(2020-05-12)When using mathematical models to computationally investigate a chemical system it is important that the methods used are accurate enough to account for the relevant properties of the system and at the same time simple ... -
Quantum Force in Wigner Space
(2014-04-08)In this thesis, I will present effective methods to study quantum dynamics using trajec- tories. Our methods are based on a method named the Classical Wigner model which starts with a quantum initial condition and generates ... -
Regulation and transport mechanisms of eukaryotic aquaporins
(2013-01-11)Aquaporins are found in all kingdoms of life where they are involved in water homeostasis. They are small transmembrane water conducting channels that belong to the ancient protein family Major Intrinsic Proteins (MIP). ... -
Regulators of Membrane Fluidity
(2020-04-29)Caenorhabditis elegans PAQR-2 (a homolog of the mammalian AdipoR1 and AdipoR2 proteins) and IGLR-2 (homolog of the mammalian LRIG proteins) form a complex at the plasma membrane that regulates fatty acid desaturation to ... -
Revealing functional details of the mitochondrial Lon Protease by NMR spectroscopy
(2023-05-11)Det mänskliga Lon-proteinkomplexet är ett ATP-beroende proteas som finns i den mitokondriella matrisen. Lon-proteinet är en produkt av den kärnkodade genen LONP1 och spelar en avgörande roll i underhåll och reparation ... -
Revealing the architecture and composition of the sperm flagellum tip
(2021-01-25)The eukaryotic flagellum is a membrane-bound protruding organelle with a cytoskeleton of microtubules. Flagella are found in unicellular as well as multicellular organisms, performing a variety of functions. Motile flagella ... -
Reverse structural biology: Cellular processes uncovered by electron microscopy
(2021-03-25)This thesis contains two projects, both using electron microscopy as the primary technique. In the first project, nuclear envelope budding (NEB) is investigated as an alternate method of transport across the nuclear ... -
Salting-out of Colloidal Latex Particles Grafted with Poly(ethylene glycol)
(2020-01-15)Colloidal particles dispersed in a medium are important both in nature and in industry. The stability of colloidal particles is determined by the interactions between them and can be improved by steric stabilization. There ... -
Secondary Organic Aerosols: Composition, Gas-to-Particle Partitioning and Physical Properties
(2019-02-21)Atmospheric aerosols influence our climate and air quality. Aerosol particles in the atmosphere are transformed through many different physical and chemical reactions. A substantial fraction of the particles in the ... -
Selectivity in the chlorate process: Hydrogen evolution and hypochlorite reduction on deposited chromium oxide/hydroxide
(2018-02-22)Abstract Production of chlorate is dependent of using sodium dichromate as a component in the electrolyte. Dichromate provides selectivity by forming a Cr(III) oxide-like film on the cathodes. Without dichromate, unwanted ... -
Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach
(2012-10-26)Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors ... -
Self-organization of nanoparticles - implications for interface biology
(2012-05-03)Cells bind to their surroundings via proteins displayed on the cell surface. These interactions support the cells and are important for many cellular processes, e.g. cell migration during morphogenesis, wound healing and ... -
Signal Transduction in Photoreceptor Proteins
(2017-10-26)The ability to sense and react to different light conditions is of great importance for many organisms on the face of the earth. Specialized proteins known as photoreceptor proteins provide bacteria, plants and animals ... -
Simplified Nonsense: New Methods for Interrogating NMD
(2023-02-20)Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral ... -
Static and Dynamic Measurements of Neurotransmitters in Drosophila Brain
(2012-11-15)Neurotransmitters, the substances neurons use for communication, and their precursors and metabolites are of obvious importance for the wellbeing of the individual and when the neurotransmitter balance is off it can lead ... -
Strong exciton-photon and exciton-exciton coupling and its effects on molecular photophysics
(2022-12-05)The energy of molecular states and their transition dynamics form the key properties to understand the photophysics of organic molecules. Strong exciton-photon and exciton-exciton couplings enable the possibility to ... -
Strong light-matter interaction and its consequences on molecular photophysics
(2020-09-15)Strong light-matter interaction offers the possibility to modify chemical and physical properties of molecules by modifying their photonic environment, resulting in the creation of hybrid light-matter states, known ... -
Structural analyses of immune cell receptor signalling and activation
(2013-04-17)Structural biology is a scientific field where the aim is to observe macromolecules on a atomic level to understand their functions. Often these macromolecules are proteins that make, almost, everything happen within the ...