Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 102-121 of 205
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Mapping ultrastructural effects of proteotoxic stress on S. cerevisiae
(2023-05-09)Cells are the basic building blocks of any living being, whether the organism consists of only one, or many cells. The different cellular components interact with one another to maintain the viability of the cell. An ... -
Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems
(2015-09-07)Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types ... -
Mechanistic Insights into Transition Metal Oxide Catalyzed Water Oxidation
(2012-05-14)A binuclear mechanism was proposed and evaluated by means of Density Functional Theory calculations. The central reaction steps were found to be the oxidation of the transition metal TM-OH moieties to TM=O and the subsequent ... -
Membrane Fluidity Regulation: From C. elegans to mammalian cells
(2020-08-12)Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing ... -
Membrane morphology and homeostasis: An electron microscopy approach
(2023-06-26)Biological membranes allow life as we know it to exist. Primarily assembled from lipids and proteins, their morphology and function can greatly vary between species or even within the same cell. They create physical ... -
Micro-Crystallization and Time-Resolved Diffraction Studies of a Bacterial Photosynthetic Reaction Center
(2019-05-27)Photosynthesis is one of the most important set of chemical reactions in nature as they can convert sunlight into hydrocarbons and chemical energy. The proteins responsible for this are two general types of reaction centers ... -
Microbial communities in anammox and nitrifying biofilms
(2017-09-19)Excess of nitrogen in water bodies causes eutrophication. One important source of nitrogen is the effluent from wastewater treatment plants (WWTPs). Nitrogen in wastewater is most commonly removed by nitrification-denitrification. ... -
Microcrystallization and structural studies of proteins by serial crystallography and x-ray scattering
(2023-09-20)Proteins are the most complex and versatile biomolecules known, with essential roles in all cellular and physiological processes. They constitute the main structural components of cells, catalyze most biochemical reactions, ... -
Microcrystallization in lipidic cubic phase and serial crystallography studies of cytochrome c oxidase
(2019-11-07)Life in all living organisms depend on chemical processes performed by proteins, which are molecular machineries encoded in the DNA. Cytochrome c oxidase (CcO) is a membrane protein essential for cellular respiration, a ... -
Microtubule structure and function as perturbed by electromagnetic fields
(2022-11-08)Frontlinjen för strukturbiologisk forskning ligger idag i att avbilda proteiner i rörelse. För att förstå hur proteiner fungerar rent strukturellt krävs avbildningsmetoder med en tid- och rums-upplösning anpassad för den ... -
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association ... -
Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
(2014-11-21)Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell ... -
Molecular biology of barnacle Balanus improvisus settlement
(2019-09-13)The aim of this thesis was to investigate molecular mechanisms of various aspects of barnacle settlement, using the acorn barnacle Balanus improvisus. This barnacle is a common fouling species and a model organism for ... -
Molecular investigations of atmospherically relevant interface processes: ice formation and water accommodation on ice and organic surfaces
(2014-05-12)Clouds and aerosols play important roles in the climate system by affecting on atmospheric chemistry, the radiation budget of the atmosphere, and the water cycle including the formation of precipitation. Climate models ... -
Molecular mechanisms of ovarian follicular development and early embryogenesis
(2014-05-19)In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and fertilizable ova for the entire reproductive life. In addition, the duration of fertility of a female is determined by ... -
Molecular pathways mediating the development of female germ cells
(2016-10-06)In mice, primordial germ cells (PGCs) dramatically increase in their number from 200 cells at 9.5 dpc to 10 000 cells at 12.5 dpc with doubling time of 12.6 hours. Thus, cell proliferation of PGCs seems a unique compared ... -
Molecular-Level Investigations of Water-Organic Systems of Atmospheric Relevance
(2020-01-07)It is known that aerosol particles may have warming and/or cooling effects on the climate and negative health effects that depend on their chemical and physical properties. However, current understanding of atmospheric ... -
MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis
(2023-10-25)Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, ... -
Multiphoton Microscopy Targeting Tissue Development. Towards the real-time imaging of epidermal differentiation
(2023-04-25)The development of novel organ-on-a-chip models calls for methodologies, which will allow the study of tissue development and pharmacological outcome in real-time. Multiphoton microscopy (MPM) has been proposed as a ... -
Nanoparticles from shipping and road traffic
(2015-05-07)In the urban environment road traffic is the dominant source of aerosol particles while in coastal and harbour areas shipping is also a significant source. For shipping there are no direct regulations regarding particle ...