Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 81-100 of 205
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Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
(2021-01-27)Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ... -
Implementation and development of serial synchrotron crystallography at MAX IV
(2023-10-11)Over the past decade, remarkable advancements in femtosecond X-ray free-electron lasers (XFELs) have brought about a profound transformation in structural biology. These XFELs have opened up exciting opportunities for ... -
Improving integration efficiency and precision of CRISPR/Cas9-mediated genome editing
(2023-09-07)The clustered regularly interspaced short palindromic repeats (CRISPR) – CRISPR-associated protein 9 (Cas9) system has revolutionized the field of genome engineering, providing a cost-effective and fast tool for targeted ... -
Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors
(2015-02-20)Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the ... -
Inhibition of the mevalonate pathway in C. elegans: Consequences and implications
(2015-09-15)The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for ... -
Integrative analysis of osmoregulation in yeast Saccharomyces cerevisiae
(2014-05-06)Similar to other unicellular organisms, yeasts frequently encounter environmental stress such as heat shock, osmotic stress, and nutrition limitations, which challenge their growth potential. To survive, all living cells ... -
Interaction of Natural Organic Matter molecules with TiO2 nanoparticles: An Experimental Adsorption and Aggregation study
(2018-08-16)Mechanisms by which synthetic nanoparticles are released into natural environments and the potential impact of nanoparticles on living organisms have been discussed frequently over the past decade. Interactions of nanoparticles ... -
Interrogation of Biological Samples by ToF-SIMS using New Primary Ion Beams and Sample Preparation Methods
(2017-01-12)Mass spectrometry is a very versatile and important technique in analytical chemistry. From atomic bombs to Alzheimer’s disease, after a century of improvements and developments there are now countless applications for ... -
Intrinsically Disordered Domains of the B Cell Receptor Cell-Free Expression and Characterization by NMR
(2014-10-23)After the last twenty years of research, the occurrence of flexible proteins without a fixed three-dimensional structure are no longer considered to be rare exceptions from the structure-function paradigm. Instead, ... -
Investigation of Exocytosis for a New Paradigm of Plasticity in Biological Systems Using Electrochemistry and Mass Spectrometry Imaging
(2021-05-05)Cellular communication is a vital process and serves as the basis for complex brain functions in multicellular organisms. The majority of cellular communication is achieved via the release of specific signaling molecules, ... -
Ion Solvation in Critical Binary Aqueous Solvents Probed by Advanced Synchrotron-Based Techniques
(2016-05-20)The Poisson-Boltzmann equation is the standard tool for studying the electrostatic interactions in electrolyte solutions, although it neglects e.g. the ion size and ion-ion correlations. Even experimentally observed specific ... -
Iron catalyzed C-C coupling reactions - mechanistic investigations
(2013-05-14)The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated ... -
Iron or Copper? - Method Development and Mechanistic Studies on Cross-Coupling Reactions
(2012-09-06)The area of catalysis has had an immeasurable impact on modern society. This has been acknowledged through several Nobel prizes during the 20th century ranging from Haber (1918) for the synthesis of ammonia to Richard ... -
Isotope labeling of proteins for spectroscopic studies
(2018-11-15)Protein structural dynamics have been closely tied to the molecular mechanisms controlling for example enzyme activities. In my work, I have mainly studied the bacteriophytochrome from Deinococcus radiodurans. Phytochromes ... -
Lanthanide-mediated C-F Bond Activation Method Development and Mechanistic Investigation
(2016-08-23)The use of transition-metals and main-group Lewis acids has proven to be an outstanding source for activation and subsequent functionalization of fluorinated compounds. However, the first is mainly limited to C(sp2)–F bonds ... -
Laser Scanning Multiphoton Microscopy – Focusing on Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging for Biomedical Applications
(2022-03-02)Laser scanning multiphoton microscopy (MPM) is considered as a non-invasive technology for three-dimensional imaging of complex biological tissues. The quantitative potential of the MPM is not investigated as much as ... -
Light and X-ray scattering investigations of microtubules subjected to oscillating electric fields
(2022-12-08)I vårt dagliga liv blir vi utsatta för oscillerande elektriska fält av olika frekvenser. Dessa fält inkluderar mobiltelefoner, wifi, bluetooth, radar för navigering, radar från bilar, kommunikationssatelliter, samt GPS. ... -
Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
(2014-03-07)Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of ... -
Lipidic Cubic Phase Microcrystallization and its Application in Serial Crystallography
(2020-10-23)Every living organism contain a cell membrane which is an important cell structure with a vast variety of different functions such as cell signaling, transportation and energy production. One of the most important functions ... -
LOOK AROUND, WHAT CAN YOU DISCOVER? The science center - a critical space for science student teachers’ development
(2021-04-21)This thesis aims to examine the opportunities and constraints on student teachers’ learning of science and teaching science when they work in small groups; planning, implementing, and reflecting upon teaching at the ...