Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 40-59 of 205
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Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
(2015-11-06)The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance ... -
Design and development of bioresponsive pseudoglucosinolates, non-cytotoxic coumarins with antibiofilm properties and studies towards the synthesis of [13]cytochalasans
(2024-12-10)The main aim of this thesis was the development of multifunctional pseudoglucosinolates (psGSLs) and artificial multivalent glucosinolates (mv-GSLs) as ITC releasing prodrugs. They were utilized as imaging, enzyme labelling ... -
Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents
(2012-01-23)This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) ... -
Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors
(2012-10-04)Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which ... -
Detecting and Identifying Solution-structural Change in Photoactive Proteins
(2015-11-27)Conformational dynamics allow proteins to fulfil their biological roles, yet the understanding of these molecular machines is largely limited to structural snapshots. Time-resolved X-ray scattering provides a possible way ... -
Determine the developmental dynamics of primordial follicles in the mouse ovary
(2014-04-15)Ovarian follicles are the basic functional units of the mammalian ovary. Progressive activation of primordial follicles serves as the source of fertilizable ova. In this thesis, by generating the Foxl2-CreERT2 and ... -
Development and application of Time-of-flight secondary ion mass spectrometry (ToF-SIMS) for skin permeation studies
(2024-01-08)The skin accounts for approximately 16% of human body weight, with a surface area of approximately 2 m2 in adults. It provides a physical barrier to the environment, maintains homeostasis by limiting the loss of water, ... -
Development and Application of ToF-SIMS for Clinical and Microbiological Analysis
(2023-02-15)The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is ... -
Development and use of an optical pCO2 sensor in marine studies
(2013-10-04)Partial pressure of CO2 (pCO2) is one of the most important parameters, which are measured in the global ocean in conjunction with ocean acidification studies. It is also a parameter of great interest to aquaculture and ... -
Development of antibody-targeted concepts for immunomodulation, biomarker imaging and enzymatic evaluation of bioresponsive pseudoglucosinolates
(2024-08-23)Nature’s vast biodiversity and its complex biological systems have long been an inspirational source for drug development. A wealth of potent, life-saving substances has been found in nature and learning from nature’s ... -
Development of Electrochemical Biosensors for Neurochemical Applications
(2018-01-04)The brain consists of billions of cells, including nerve cells, which have the ability of transforming an incoming electrical signal in to a chemical output by the release of neurotransmitters through a process called ... -
Development of Fluorescent Nucleobase Analogues - Intrinsically labelled nucleic acids for molecular binding investigations
(2019-09-04)This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e. ... -
Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
(2013-09-05)It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and ... -
DNA checkpoint override and redox signaling in Schizosaccharomyces pombe
(2019-10-25)This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to ... -
Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals
(2014-05-15)The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing ... -
Dynamic regulation of the Mig1 transcriptional repressor under glucose de/repression
(2016-11-24)The budding yeast Saccharomyces cerevisiae AMP-activated protein kinase/SNF1 is a member of a highly conserved protein family present in all eukaryotes. Snf1 regulates energy homeostasis; in yeast, it is best-known for its ... -
Effect of Microwaves on Microtubule Structure and Function probed by Light and X-ray Scattering
(2018-02-15)We are constantly exposed to radiation in some form or another from our environment. High frequency electromagnetic radiation, including ultraviolet light and X-rays, cause damage to living organisms due to ionization ... -
The Effect of Site-Specific Mutations on hIAPP Fibril Polymorphism: A Cryo-EM Study Towards Potential Inhibitors
(2024-01-25)The development of amyloid deposits in tissues, as a consequence of the self-assembly of misfolded proteins, is a critical pathological feature in a range of diseases, including neurodegenerative disorders and metabolic ... -
Electrocatalytic properties of Ni hydroxides with Zn or Co in the Ni matrix
(2014-01-17)The majority of the work in this thesis has been made with the improvement of the systems for electrochemical co-generation of chemicals and electricity in mind. This is an appealing but challenging way of producing chemicals ... -
Electrochemical and microscopic analysis of chemical signalling in biological systems
(2019-10-01)Cellular communication is a prerequisite in multicellular organisms in order to survive. Many times, this communication occurs through the highly controlled and regulated release of chemical signals through a process known ...