Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 25-44 of 205
-
C. elegans PAQR-2 ‒ A Regulator of Membrane Homeostasis
(2016-04-26)The progestin and adipoQ receptor (PAQR) protein family is characterized by a 7-transmembrane domain, and a topology reversed that of G-protein coupled receptors, i.e. the N-terminus resides in the cytoplasm. Despite the ... -
Carbonaceous Aerosol in Europe - out of the woods and into the blue?
(2015-09-03)Particulate matter (PM) in the atmosphere influences weather and climate and may have important health impacts. Regional scale chemical transport modelling aims to describe the composition of particulate matter, to track ... -
Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2
(2022-05-04)Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which ... -
Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations
(2012-08-30)Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain ... -
Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae
(2016-05-12)All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form ... -
Character and Function of Anammox Bacteria under Environmental Stress
(2013-09-16)During the last few decades observations of novel processes involved in nitrogen transformations have fundamentally challenged the view of pathways and controlling mechanisms during local and global nitrogen cycling. ... -
Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge
(2015-09-09)ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, ... -
Characterization of Eukaryotic Aquaporin Regulation
(2024-05-15)Aquaporins, as transmembrane proteins essential for cellular water balance maintenance, are increasingly recognized for their modulation by protein-protein interactions, often implicated in various human pathologies. This ... -
Computational Studies of UV-B Induced Signalling Pathways in Plants
(2017-05-18)Abstract This thesis presents theoretical studies of UV-B induced signaling pathways in plants using molecular dynamic methods combined with (TD)-DFT calculations. Ultraviolet B (UV-B) radiation is a component of sunlight ... -
Computational tools for the analysis of time-resolved serial X-ray crystallography data.
(2024-11-22)Many transmembrane proteins play an essential role by facilitating energy transduction in various biological systems. Whether powered by light, as in bacteriorhodopsin or photosynthetic reaction centres, or by oxygen ... -
Computer-aided drug design approaches in developing anti-cancer inhibitors
(2016-11-23)The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. Nowadays, ... -
Conformational dynamics of rhodopsins revealed through time-resolved X-ray structural studies
(2024-09-12)Light plays a crucial role in shaping biological processes, influencing growth, behavior, and survival from microorganisms to complex animals. At the molecular level, specialized proteins detect and respond to light, ... -
Conformational Flexibility in Protein Function: Dynamics of S100A4, Photosynthetic Reaction Centre and the Prenylating Enzymes UbiA and MenA
(2014-09-11)Proteins are the most versatile macromolecules and they are essentially involved in the biological processes throughout all living organisms. The three dimensional structure of proteins and their dynamical properties ... -
Correlative Chemical Imaging of Nanoscale Subcellular Structures
(2023-05-10)Chemical imaging can elucidate complex mechanisms, relationships, and components of biological samples. For example, it can reveal properties such as chemical composition, chemical structure, reactivity, and topography. ... -
Creating Optical Activity: Total Spontaneous Resolution and Viedma Ripening
(2017-10-18)The creation of optical activity has been considered as something impossible even though reports of such creation via total spontaneous resolution since the 1940´s have been published. More recently Viedma ripening have ... -
Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
(2015-11-06)The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance ... -
Design and development of bioresponsive pseudoglucosinolates, non-cytotoxic coumarins with antibiofilm properties and studies towards the synthesis of [13]cytochalasans
(2024-12-10)The main aim of this thesis was the development of multifunctional pseudoglucosinolates (psGSLs) and artificial multivalent glucosinolates (mv-GSLs) as ITC releasing prodrugs. They were utilized as imaging, enzyme labelling ... -
Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents
(2012-01-23)This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) ... -
Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors
(2012-10-04)Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which ... -
Detecting and Identifying Solution-structural Change in Photoactive Proteins
(2015-11-27)Conformational dynamics allow proteins to fulfil their biological roles, yet the understanding of these molecular machines is largely limited to structural snapshots. Time-resolved X-ray scattering provides a possible way ...