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Selen och incidens av typ 2-diabetes - en systematisk översiktsartikel

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Title: Selen och incidens av typ 2-diabetes - en systematisk översiktsartikel
Other Titles: Selenium and incidence of type 2 diabetes - a systematic overview
Authors: Emma Dalman, Ulrika Eriksson
Issue Date: 22-Feb-2012
Degree: Student essay
Series/Report no.: DIE/H08
Keywords: diabetes mellitus type 2
blood glucose
non-insuline dependent
Abstract: Bakgrund: Typ 2-diabetes är en sjukdom som kan ge kärlskador, stroke och för tidig död. Oxidativ stress tros spela en viktig roll i utveckling av insulinresistens och diabetes. Selen är ett naturligt förekommande mineral som är involverat i att skydda mot oxidativ stress. Det har bedömts att selen skulle vara fördelaktigt i prevention av sjukdomen, dock har situationen ändrats då studier funnit positiva samband mellan höga nivåer och incidens av sjukdomen. Syfte: Att granska de studier som ... more
Description: Background: Type 2 diabetes is a disease which causes vascular damage, stroke and premature death. Oxidative stress may play a role in the development of insulin resistance and diabetes. Selenium is a mineral involved in the protection against oxidative stress, and has been thought to be favorable in the prevention of the disease. However, this has changed since trials observed positive correlations between high selenium levels and incidence of type 2 diabetes. Objective: To examine the studies that investigates seleniums effect on the incidence of typ 2 diabetes Search strategy: Searches have been done in PubMed and Scopus. Selection criteria: Included studies were human studies in English/Swedish with RCT or cohort design with the aim to investigate the correlation between selenium and incidence of type 2 diabetes. Excluded studies were studies whose aim was to investigate the role of selenium in patients with existing diabetes. Studies regarding pregnant women, animals or children and with in vitro design were also excluded. Of the studies found in Scopus where MeSH terms were available, the ones who did not include relevant terms were excluded. Data collection and analysis: Studies were collected according to the aforementioned criteria. They were analyzed with Granskningsmall för randomiserad kontrollerad prövning made by SBU or with Gransknings- och dataextraktionsmall för kohortstudier from the University of Gothenburg. Main results: Three studies were selected for this systematic overview. One of these was an RCT and two were cohort studies. The RCT and one of the cohort studies showed a positive correlation between a high selenium intake and incidence of type 2 diabetes. The third article came to an inverse conclusion, however it cannot be said to completely contradict the results from the other two studies, regarding the amounts of selenium investigated. Conclusions: There is moderate evidence that selenium affects incidence of type 2 diabetes. Consumption of selenium above recommended intake is assumed to result in an increased risk to develop type 2 diabetes, with a positive exposure-response gradient. Plasma selenium around 1.32-1.44 μmol/L is suggested to implicate the lowest incidence of type 2 diabetes, and levels around 0.90 μmol/L and 2.40 μmol/L to increase the risk of the disease. More research is needed to determine optimal amounts of selenium considering type 2 diabetes.
Appears in Collections:Kandidatuppsatser, Dietistprogrammet



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