Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Now showing items 1-20 of 505
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Drug interactions in healthcare - Knowledge resources and clinical management
(2025-01-14)Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ... -
Gravitostat: A Homeostatic Regulator of Body Weight
(2025-01-14)This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ... -
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ... -
The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system
(2025-01-08)Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ... -
Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Adult psychiatric outpatients; neuropsychiatric, neuropsychological and neurodevelopmental aspects
(2024-12-05)ABSTRACT Background: Neurodevelopmental disorders - including autism and attention- deficit/hyperactivity (ADHD) - are relatively common in the general population with a total prevalence rate of at least 10%. Most research ... -
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
(2024-12-04)Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ... -
Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up
(2024-12-04)The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ... -
Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation
(2024-11-20)Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ... -
Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome
(2024-11-19)Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ... -
Novel biomarkers for parkinsonian disorders
(2024-11-12)Parkinsonian disorders (PS) are a heterogeneous group of neurodegenerative diseases characterised by the presence of parkinsonism. Parkinson’s disease (PD) is the most common PS, characterised by the accumulation of ... -
Endocrine and neural mechanisms in metabolic control
(2024-11-11)The regulation of eating behavior and metabolism is governed by complex inter-actions between central and peripheral signals, with hormones such as oxytocin (OT) and glucagon-like peptide-1 (GLP-1) playing pivotal roles. ... -
The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease
(2024-09-26)The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ... -
Social and motor coordination: methods development and applications in ESSENCE
(2024-09-24)This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ... -
Survival of patients with glioblastoma - advancements in the past two decades
(2024-09-24)Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ... -
Thoracic Mobility in Cystic Fibrosis Care
(2024-08-19)Introduction: Cystic fibrosis (CF) is an incurable and highly life-limiting hereditary disease. However, due to significant medical advancements over recent decades, life expectancy has risen to close to 50 years. As such, ... -
Physical Activity Before and After Stroke - Examining Stroke lncidence and Outcomes
(2024-05-24)Background: Stroke is a leading cause of death and disability worldwide. A physically active lifestyle may prevent stroke and decrease the consequences of a stroke. Physical activity is also an important component in ... -
Ge de ohörda rösterna upprättelse - framsteg och utmaningar vid involvering av sköra äldre personer i forskning om åldrande och hälsa
(2024-05-16)Introduktion: I Sverige och globalt har vi en demografisk utveckling med en allt större del åldrad befolkning. Forskning om åldrande och hälsa har därför en allt viktigare roll i samhället. Samtidigt är det just nu en ... -
Meningiomas - consequences of incidental detection and novel classification
(2024-05-06)Aim Meningiomas are often benign, slow-growing tumors found in older individuals. This thesis aimed to examine the occurrence of incidental meningioma, the surgical and quality of life outcomes after surgery and to evaluate ... -
Visual function and functional vision – ophthalmological perspectives on a normal population
(2024-05-03)Aim: The aim was to investigate visual function and functional vision in 70-year-olds in Gothenburg Sweden. Methods: A group 1203 randomized 70-year-olds completed questionnaires on somatic, social health, and well-being. ...