Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ...

Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after ...

Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells ...

Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation ...

Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ...

Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of ...

Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood ...

Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ...

Epitranscriptomics involves covalent modifications of RNA bases, with N6-methyladenosine (m6A) being one of the most abundant and functionally characterized. This modification plays a key role in RNA metabolism, cellular ...

In this thesis we aimed to unravel the importance of Alkal2 in neuroblastoma with the aid of preclinical murine models. We tested the hypothesis that Alkal2 can potentiate murine MYCN-driven neuroblastoma in absence ...