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HIV Persistence and Viral Reservoirs
(2010-05-28)
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting ...
On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)
HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ...
Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects
(2021-02-11)
From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however ...
On HIV in the elderly and vitamin B metabolism in HIV infection
(2022-01-17)
The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the ...
Antiretroviral treatment of HIV-1 in the central nervous system
(2007-05-24)
HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will ...
On HIV-1 latency and viral reservoirs
(2015-05-11)
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and
anatomical reservoirs. This thesis concerns several problematic issues of HIV-1
persistence, including ways to measure and monitor ...
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)
HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ...