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A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
(2013-08-23)
This thesis aimed to explore the regulatory roles of mast cells in vaccination. Mast cells have been increasingly recognized as important orchestrators of immune regulation in both health and disease, in addition to their ...
Epidemiologic studies on human enteric viruses in Cameroon
(2013-11-27)
Enteric viruses are a diverse group of viruses that include those that multiply in the intestinal epithelium and cause gastroenteritis, and those that first multiply in the intestine and then spread to extra-intestinal ...
Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis
(2018-10-23)
Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against ...
Biolubrication: Structural investigation of lubricin and its glycosylation
(2014-11-04)
The sliding articular cartilage surfaces of the human diarthrodial joints are surrounded by
biolubricating synovial fluid (SF), creating a perfect low friction biological biobearing
structure with excellent lubrication ...
Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
(2013-11-11)
The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of ...
Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood
(2017-10-17)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. Hematopoietic stem and progenitor ...
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)
Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ...
Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome
(2014-11-06)
Cytomegalovirus (CMV) infection is a common opportunistic infection after heart and lung transplantation. The aims of this thesis were to relate the incidence and severity of CMV infection and disease to different forms ...
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)
Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ...
Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)
Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ...