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COX-2 Gene Expression in Colon Cancer Tissue related to Regulating Factors and Promoter Methylation Status


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Title: COX-2 Gene Expression in Colon Cancer Tissue related to Regulating Factors and Promoter Methylation Status
Authors: Gustafsson Asting, Annika
Carén, Helena
Andersson, Marianne
Lönnroth, Christina
Lagerstedt, Kristina
Lundholm, Kent
Issue Date: 13-Jun-2011
Publication type: article, peer reviewed scientific
Organization: Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden
Citation: BMC Cancer. 2011 Jun 13;11(1):238
Abstract: Abstract Background Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. Method Tumor and normal colon tissue were collected at primary curative operation in 48 unselected patients. COX-2 expression in tumor and normal colon tissue was quantified including microarray a... more
ISBN: http://dx.doi.org/10.1186/1471-2407-11-238
Description: © 2011 Asting et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2077/26360
Appears in Collections:Articles / Artiklar Institutionen för kliniska vetenskaper

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